syndrome

Low T3 syndrome V: should it be treated with thyroid hormone?

November 22, 2011 in Thyroid Disorders | 39 comments

In this final article in the series on Low T3 Syndrome, we'll discuss whether thyroid hormone replacement therapy is an appropriate treatment in these cases. Unfortunately, there are few studies that have examined this question specifically, and even fewer that have explored the question of whether T4 or T3 (and which type of each) would be the best choice. As a clinician, my primary concern is always primum non nocere, or "first, do no harm." From this perspective ...
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Low T3 Syndrome II: myths and misconceptions

September 15, 2011 in Thyroid Disorders | 23 comments

In Low T3 Syndrome I, I introduced the Low T3 Syndrome (a.k.a. Euthyroid Sick Syndrome, Non-Thyroidal Illness Syndrome), provided some background on thyroid physiology and metabolism, and emphasized the fact that Low T3 Syndrome is not caused by a problem in the thyroid gland itself. In this article we're going to discuss common myths and misconceptions about Low T3 Syndrome and problems diagnosing it in a clinical setting. This is important because there's a lot of chatter around ...
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Low T3 Syndrome I: it’s not about the thyroid!

September 1, 2011 in Thyroid Disorders | 37 comments

Hypothyroidism involves high levels of thyroid stimulating hormone (TSH) and low levels of the thyroid hormones T4 and T3. However, in my clinical practice I frequently see people with low levels of T3 with normal T4 and either low or normal TSH. This condition has been reported on in the medical literature for years but it is rarely acknowledged or discussed in conventional medical settings. Most doctors (even endocrinologists) do not seem to know what causes it, ...
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Think skinny people don’t get type 2 diabetes? Think again.

September 19, 2010 in Diabesity | 35 comments

In the last article we discussed the complex relationship between body weight and type 2 diabetes (T2DM). We learned that although obesity is strongly associated with T2DM, a subset of "metabolically healthy obese" (MHO) people have normal blood sugar and insulin sensitivity and don't ever develop diabetes. In this article we're going to talk about the mirror reflection of the MHO: the "metabolically unhealthy nonobese" (MUN). These are lean people with either full-fledged type 2 ...
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