UTIs can be caused by poor hygiene, impaired immune function, the overuse of antibiotics, the use of spermicides, and sexual intercourse. The most common cause, accounting for about 90 percent of all cases, is the transfer of Escherichia coli bacteria from the intestinal tract to the urinary tract.
For those of you who have experienced a UTI, there isn’t much you wouldn’t do to avoid another one. While I personally have never had a UTI, my patients have told me how symptoms like pain, burning, nausea, and even bloody urine can be debilitating, and for those who get chronic UTIs, the fear of infection can be enough to prevent engagement in any activities that could trigger one. For people who get them frequently, sometimes a specific cause cannot even be pinpointed. This can be frustrating and scary.
Fortunately, there are a few methods of natural UTI treatment and prevention that have worked extremely well for my patients, to the point where they no longer worry about getting a UTI.
These treatments don’t require a prescription, are inexpensive, and are completely drug-free. While your doctor may not know about them, I hope this article will help you completely avoid UTIs—or at least significantly reduce their frequency and severity. I recommend working with a Functional Medicine practitioner who is focused on treating the root cause of your UTIs.
UTIs can be debilitating, but it is possible to get relief without requiring a prescription. Check out this article for five ways to cure UTIs without antibiotics. #functionalmedicine #wellness #chriskresser
What Is the Standard Treatment for a UTI?
Doctors typically use antibiotics to treat UTIs, and the type and duration depend on your health condition and the type of bacterium found in your urine. (2) Commonly prescribed antibiotics are:
- Trimethoprim/sulfamethoxazole (Bactrim)
- Amoxicillin
- Ampicillin
- Ciprofloxacin (Cipro)
These antibiotics are often unnecessary and may cause more problems in the future by destroying the beneficial bacteria that prevent pathogenic bacteria from growing. Long-term use of antibiotics can also lead to antibiotic resistance in strains of bacteria like E. coli in the gut, and a UTI caused by these bacteria will be even more challenging to eliminate and can cause more serious issues like a kidney or bladder infection.
Furthermore, antibiotics do very little to prevent the infection from happening in the first place. So, while drugs may be an easy fix for the short term, in the long run, you will continue to be susceptible to UTIs, and these infections may be worse than if you had never taken a course of antibiotics in the first place!

Curing and Preventing UTIs Naturally: D-Mannose
Treating UTIs with D-Mannose
D-mannose is by far the most effective supplement for both treatment and prevention of UTIs. Similar to glucose in structure, D-mannose is a naturally occurring sugar that is found in a number of fruits, including apples, blueberries, and cranberries. (3) This sugar is the reason that cranberry juice has been commonly recommended as a UTI treatment, though it is far easier to get the recommended dosage from a supplement. D-mannose is effective because it attaches to E. coli bacteria, causing them to stick to each other and preventing them from sticking to the walls of the urinary tract. (4) The bacteria can then easily be eliminated from the body during urination.
D-mannose, even in large quantities, does not cause any adverse effects, and cannot be metabolized the way other sugars can, meaning this supplement is safe for people with diabetes and others who are avoiding sugar for any reason. This treatment is also safe for children and the elderly.
Symptom relief can be seen as quickly as the following day, and most symptoms of UTI are generally resolved after 48 hours of treatment. Additionally, taking D-mannose during a time where you feel you are most prone to UTIs, such as before intercourse or during prolonged antibiotic treatment, can help prevent a UTI from ever developing in the first place. This is especially helpful for those who are prone to chronic UTIs and want to be able to engage in normal life activities without fear of infection.
The typical dose of D-mannose for UTI treatment is 500 mg, in capsule or powder form, taken with or in a glass of water or juice every two to three hours for five days. It is a good practice to continue taking the supplement even after symptoms have diminished to ensure complete elimination of the bacteria in the urinary tract. This dose can also be taken as a preventive, or prophylactic, method.
While there has not been any peer-reviewed research to support the effectiveness of D-mannose in treating or preventing UTIs, clinical and anecdotal experience suggests it is highly effective for the majority of infections, both acute and chronic. Some of my patients who have used D-mannose as a UTI treatment method have even described its effects as “miraculous”—so it’s definitely worth a shot!
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Four Alternative Treatments for Chronic UTIs
One caveat with D-mannose is that it is only effective with UTIs caused by E. coli infection. While this accounts for about 90 percent of cases, 10 percent will not benefit from this treatment. In this case, supplements that help disrupt biofilms can be useful in treating and preventing UTIs.
Biofilms are an accumulation of microorganisms and their extracellular products forming structured communities attached to a surface such as the lining of the urogenital tract. (5) The development of a biofilm can make infections extremely hard to treat, since they commonly return shortly after treatment is stopped.
The antibacterial resistance of pathogenic biofilms is one of the major reasons why those who get a UTI are highly susceptible to getting more in the future—if the biofilm is not completely eliminated, the infection will eventually return at some point.
1. InterFase Plus and Biofilm Defense
This is why the use of biofilm disruptors can be helpful for preventing the recurrence of chronic UTIs. The biofilm disruptors that I recommend to my patients are InterFase Plus from Klaire Labs or Biofilm Defense from Kirkman. These contain specialized enzymes to disrupt the biofilm matrix embedding potential of pathogens, and dissolve the sugar and fibrin components of most pathogenic biofilms. By destroying the biofilms, the recurrence of UTIs despite proper hygiene can be reduced. (6)
2. Lauricidin
Lauricidin is another supplement that may help in treating UTIs, particularly those that are caused by types of bacteria other than E. coli. Lauricidin (a proprietary form of monolaurin) has antiviral, antifungal, and antibacterial activity, and is specific against pathogenic bacteria so it won’t disrupt beneficial bacteria in the gut. It is highly effective at combating gram-positive bacteria in the families of: (7)
- Streptococcus
- Staphylococcus
- Corynebacterium
- Listeria
- Bacillus
- Clostridium
It works by disturbing the integrity of the bacterial cell membrane, blocking replication and making it easier for the immune system to destroy the pathogen. Lauricidin is only helpful, however, for UTIs not caused by E. coli, which is gram-negative and has a different kind of outer cell membrane than gram-positive bacteria.
3. Nattokinase
Nattokinase is another enzyme that has been shown to dissolve biofilms. (8) Produced by the bacteria found in the fermented food natto, this enzyme is proteolytic and can help break down the fibrin proteins that maintain the structure of biofilms.
Because of its fibrin-breaking ability, it’s important that nattokinase supplements are not taken by people with bleeding disorders, or by people who are taking Coumadin (warfarin), aspirin, or any other drug that influences blood clotting, unless supervised by a physician.
4. Apolactoferrin
Apolactoferrin (or lactoferrin) is one more supplement that I recommend to my patients with recurrent UTIs. This multifunctional protein lactoferrin is a component of the immune system with antimicrobial activity, and is part of the innate defense, found mainly in secretions and mucosal surfaces. (9)
Lactoferrin has been shown to block pathogenic biofilm development by binding to iron and causing the bacteria to “wander” across surfaces instead of forming cell clusters and biofilms. (10, 11) One study found that the amount of E. coli bacteria in the kidneys and bladder of mice was significantly reduced 24 hours after oral lactoferrin treatment, compared to a control group. (12) More research is necessary to demonstrate the effectiveness of lactoferrin in treating UTIs, but I believe it is worth trying, especially if dealing with chronic UTIs.
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I would like to comment on a regimen that I find extremely effective at banishing my UTIs that would otherwise need antibiotics. I tried the d-mannose approach early on, but as noted it is only effective against e-coli bacteria. Later on, d-mannose no longer worked for me. My tests have come back with numerous offending bacterias, most likely because the biofilms are so difficult to disrupt. You want to look for broad spectrum antibacterials. It would also help to narrow down the offending bacteria in order to find an antimicrobial that would be most appropriate.
I second the biofilm disrupters above, but I have been having great success with olive leaf extract (tincture or capsules), with tumeric capsules. Tumeric happens to be a biofilm disrupter. Olive leaf is a very broad spectrum herbal antibiotic, probably one of the most potent there is. When I was taking it alone, it worked 90% of the time, but it wasn’t always strong enough. The combo of olive leaf and tumeric seems to be most effective. I’ve nipped every UTI in the bud since. Look up acute doses for olive leaf. I take 180mg per day of oleuropein divided into 4-5 doses. You need to check your extract to see how much oleuropein is included in each capsule or tincture dose. It will vary. I hope this helps someone out there as much as it has helped me.
Antibiotics should be a last resort, but I know how panicked we can get to reach for them with UTIs. If you are in a lot of pain and are peeing blood I recommend an antibiotic. Cranberry juice and d-mannose are not likely to help you then. I recommend olive leaf and tumeric for recurring UTIs and if they do not relieve you of the burning sensation I recommend seeing a doctor. I think the key to prevention if a biofilm disrupter and an appropriate antibacterial agent for your specific strain. There aren’t too many different UTI offenders though and olive leaf seems to work against quite a few. If you have impaired immunity, you should also look into working on that with nutrition and other herbs.
I also want to recommend taking a bath with about 10 drops of thyme essential oil, you can mix it with tea tree and lavender as well, but thyme seems to be most effective at eradicating my urinary infections pretty instantaneously, post-bath. Mix the essential oils with a carrier oil before adding to the bath. If this does not help you, carry on with the biofilm disruptors and the olive lead and tumeric I mentioned above.
Through a car accident many years ago an injury was that my ureatha was damaged which now causes the bladder not to empty properly and get severe bladder infections I catheterised every day, through taking so many antibiotics I still get infections have just started using d manose and coconut water plus a very health diet (no sugar) was wondering if apolactoferrin would help me and where do I purchase it from.
I have had a uti for about 3 months now and have been to the doctors twice and have been on 2 different antibiotics and nothing seems to fix it they took a culture of my urine and said there was no bacteria I have no insurance and I’m feeling very discouraged.. the doctors that have seen me have told me to see someone else but I just can’t afford too.. I’m losing all faith..
If u have had a UTI for five days and pregnant, I think u need to see a traditional doctor. Don’t fool around with new things at this point. I am all about holistic and or supplements but if Uti’s are not treated after a few days, it can turn into a kidney infection. Good luck!!!!
Could someone please tell me if any of these biofilm disruptors are safe during pregnancy? Or at least not notably unsafe? Thinking of taking one today –uti hasn’t gone away in five days in spite of every natural remedy I could find.
Chris, I am a 39 year old male and have had a constant urinary tract infection for just over 2 years now. I realize that this is very uncommon in men. I have taken to the internet to do my own research as no doctors have been able to treat my infection or find out what infection I have. I have been perscribed Cipro, doxycycline and now just finishing a 10 day perscription of Macrobid that is not working. I realize the side effects of these antibiotics and try and use them as little as i can to control my infection, but if I go say approximateley 5 days without taking a doxycyline pill I will start peeing almost straight blood and then have white puss come out. The pain when I am peeing or slowly dribbling out blood is undescribeable. If I then take a Doxy pill, almost exaqctly 3 hours from taking it the blood, puss and most of the pain will go away, I can pee almost normal again but I still feel the urinary tract infection especially when i first start to urinate. The Doxy however controls the bacteria from multiplying and lets me still live a some what normal life. I have seen a Urologist that did a scope on me and I was told I have no blockages in my urinary tract and a very healty bladder. He then told me that there is nothing he can do for me from here. I am very scared to keep taking these antibiotics. I am willing at this point to try anything else, i am at a complete loss of knowing what to do and I have become really depressed over this. I realize this is way more common in women but is there any men that have had any of these symptoms? D-Mannose but am also willing to try any other suggestion. I have no idea where to go from here now that the uroligist that i waited to get into for over a year has now told me there is nothing else he can do.
@Chris I just wanted to add a male voice of support. I’m 43 and have suffered from chronic UTI for three years now. My symptoms have not been as severe as yours but I have tried so many things its hard not to become discouraged.
I had great hope in D-Mannose but it had no effect. Did you find something that worked for you eventually? I really hope so.
I just purchased D-Mannose and Biofilm Defense. I have gotten a uti followed by a yeast infection every month after my pregnancy about 4 months now. I think its hormones. My doctor keeps giving me antibiotics. What should my D-mannose – Biofilm regumine? How often should I take each?
Danielle, be sure to take probiotics regularly after antibiotics!!!
I am past menopause. After having kidney stones and many UTI infections I finally found relief. Been taking d mannose with cranactin and a hormone cream estrace. My world has changed.
Hi Chris,
I’ve been taking BioFilm Defense as a preventative measure. I randomly started it last Wednesday. Am I to finish the whole bottle? I had a UTI a month ago and managed to cure it with dmannose.
I have been taking lactoferrin for almost two weeks two times a day for the treatment of hep c. My stools are back to normal and will have blood taken again on Dec. 19th. I really feel it is working! Has anyone else taken it? One thing I noticed is that now when I take it my urine is discolored and has a strange odor first thing in the morning. Is this common. It is totally clear after I drink water.
I am a 3 year breast cancer survivor with no money and because of my genotype the usual interrfon would not give me a good chance of curing it. But, I’m trying to be as proactive as possible and this seems to be working. I was diagnosed in 2003 and I believe I contracted it in the early seventies.
Any advice would be appreciated.
I also have had a history of reacurring UTI’s and I am currently on nitrofurantoin, generic for macrodantin, and it is getting too expensive. Thinking about trying the d-mannose do you think that is ok? I also have the ecoli strain and this is the only antibiotic I can take but I don’t want to become antibiotic resistant.
The last few times I felt a UTI onset, I used this remedy: 16 oz of unsweetened 100% cranberry juice (this stuff is TART), every day for 3 days. For every 16 oz of water I put in my stainless steel bottle, I mixed in 4 ounces of cran juice. By the end of the first day it alleviated most of the pain. By day 3 the symptoms were gone!
Hi. I have been struggling with an antibiotic drug resistant ecoli bacteria that goes into my kidneys and causes me to be very weak and I get back pain and my muscles burn when I use them.( I was told this is due to dehydration.) I take the IV antibiotics which has damaged my eyes hopefully temporarily. Then I’m sick again within a week to 10 days. I tried the powdered D-manose which did not work. The powder tasted very sugary. I am also diabetic and the doctor said that the bacteria thrive on sugar. So I don’t think I can take sugary stuff like D-manose. What do you recommend for me. I am very concerned that antibiotics destroy DNA, protein and mitocondria. I need to get off the antibiotics. What can I do?
Thanks.
Thank you for your great information.
What is your opinion about Colloidal Silver by acute UTI?
Thank you.
Update: So, my urine test came back negative after having pain and symptoms. I had skipped the d mannose this time and pounded water with equal results. My NP says we are going to start thyroid support and I’ve been on cortisol in the am for about 1 1/2 months. Scared and excited.
april, this is exactly what i am going through now. my last two tests came back clean yet i feel horrible. i just started d mannose so we will see. dont know anything about cortisol. can you educate me?
thanks
I would google cortisol. I’m not on it spec for UTI’s. I think it helps your body deal w/ stress and infections better. I tested low in the am for it, it’s adrenal support. I’m so sorry you’re having to deal w this too. It’s terrible- unpredictable and sick all the time when I’m not sick. D-mannose hasn’t helped me- i don’t think- maybe. It makes me feel worse and poop tons. Google interstitial cystitis also. I suspect this. I’m still learning. This is a great resource. I’m down for comparing notes! I am on bio Identical hormones, I guess the estrogen helps plump things up but it hasn’t made them go away either. There’s so much u certainty and wondering and trying to figure it all out. I suspect the Hashi’s has me out of whack and hope her remedy helps. PS the bio hormones helped many things a lot. My moods are much more stable. What’s your story?
I’m experiencing bladder infection issues now and am researching to find a cure, or some type of effective treatment. I, too, have been told by an MD that there is no bacteria, but I’m convinced there is. I know exactly when it started, and bacteria was involved. The info on this site about types of bacteria is most helpful, and will provide fodder for further investigation, and also to share with my Dr. if I need to go back.
Here’s a link that also was informative: (info is dated, but is it still relevant? If so might explain why so many of our bacterial infections are being missed)
http://www.ic-network.com/guestlectures/bjtranscript.html
In the QA section of the lecture, she mentions that most labs culture bacteria in an agar medium. Apparently some bacteria that exist in the bladder don’t grow on this medium, but do grow in a liquid medium — the Dr. mentioned who discovered this used a soy broth. Apparently the agar medium is a newer culture medium technology, and labs don’t as a matter of course use the older liquid medium technology any more.
The newer culture methods apparently are missing our infections. I’m still researching this myself, but I’m sharing in case anyone else having the same issues – bladder pain, urge frequency — all supposedly without a bacterial infection according to a dip stick or culture — and has time to research and share. I’ve been at it for almost 3 hours today, and have to stop now.
It would be great to know of a lab that still uses a liquid medium, to tell our Drs. or send in our own urine for a culture. I’ve been told that I need to have a camera stuck up my bladder etc, etc. Ugh. I know this is some type of bacterial infection… I don’t need all that bladder drama!
By the way, I’m controlling symptoms until I find a cure with D-Mannose and Cranberry pills 3x per day, as well probiotics for women’s vaginal and urinary areas at double the 50 billion dose AM and PM, and a regular probiotic with the middle D-mannose & cran pill dose. I’m a large woman, 5′ 8″ and 200 lbs, so someone smaller would likely need less.
As a Practitioner in the women’s health field (holistic) I know all too well the devastation that Cipro can cause (how about permanent pudendal nerve damage in a client) and with my 2 second uti of my life, the last one 25 years ago I will do anything to preserve my gut from antibiotics. I’ve been taking the d-mannose for 4 days with no change so thanks to Chris’ article I will be moving to the monolaurin and biofilm dispruptors feeling confident it’s not e-coli.
Hi your site is the best resource I’ve found besides my NP. Thank you. I’ve had chronic UTIs/ic/?? for about a year and a half- up to 3 per month never a month without. I’m f, 43, and just took a test to determine bacteria type/info. I’m pretty sure I have Hashi’s along w tons of autoimmune issues. I’m doing most things right and still suffering as much as ever. D mannose makes my ibs (often at same time) worse and makes me feel terrible esp when I’m already feeling bad. What are the next steps you would recommend? Also my body reacts to so many things and foods and chemicals I am going crazy and miserable. Help!
I share some of your sensitivities to chemicals. You may have a MTHFR gene mutation, like I and apparently many people do. It affects the liver’s ability to detoxify heavy metals and chemicals such as car exhaust and cigarette smoke, to name a few. As the body burden of these substances builds up, so do the sensitivities. You can google MTHFR mutation and find out a lot. Dr. Neil Rawlins has done a lot of research.
Find an MD or practitioner who specializes in Environmental Medicine. The Detoxigenomic profile is a gene test that identifies genetic issues with detoxification. Sauna treatment, chelation, and certain supplements to help the liver may stabilize or reverse some of the sensitivities.
Visit an Environmental MD’s site http://www.bernhoftcam.com and read Dr. Bernhoft’s personal story in the link about him for more info. His diagnosis and treatment protocol has helped me a lot with toxic issues. I’m still searching for help with urinary issues though.
Hi,
I have Hashi’s too and the other issues you mentioned. I am able to improve my chemical sensitivity by taking sublingual pantethine as well as sublingual coenzymate b complex. I use source naturals. I also have to be sure to eat meat a couple times a day with cheese and some bread. Those specific combo help ease my sensitivity. It basically supports my adrenals. Try looking into nutritional balancing by Dr. Lawrence Wilson or TEI.
I just had my first UTI and used D mannose because its what works for my kids. However, I ended
up in the emergency and on antibiotics, which I haven’t taken except during my C-sections.
The bacteria was E Coli. I was shocked that the D mannose didn’t work or my homeopathic.
I had bleeding for one day and not burning, but stabbing pain when urinating, no fever, and back
pain and a bloated stomach. Almost done with antibiotic, yet so surprised that it was E Coli and these
remedies didn’t touch it…. Any thoughts????
I have had chronic e-coli uti’s for about 2 years and was on antibiotics for about a year until I realized that they were probable making the problem worse despite the fact that they were not working. I am doing some cleansing for the kidney and bladder (Dr. Schultze) and am about to go on the PH Miracle diet. It has gotten to the point that I have Chronic Fatigue from it. I was wondering if you have had any luck with the biofilm disruptors and e-coli infections. I have tried D-Mannose and it has not worked for me. Thanks for all that you are doing to help women like myself who are suffering with this problem,
More likely it’s yeast, which can present just like a uti. Get treated for yeast. Then get plain, organic yogurt, a sterile syringe (25cents at any pharmacy, no needle of course), and sleep with it in your vagina over night for many nights. You should improve fast. Make sure it has “live” cultures, better yet make your own. Then do the SCD diet so the yeast comes under control.
I’ve been diagnosed with a UTI after having my yearly check up. I wasn’t aware I had one. I still have no symptoms. Upon initial diagnosis, my doctor put me on Macrobid 3x day. After taking one dose of the Macrobid, I had a headache, sore throat, fever and felt like I’d been hit by a truck. I stopped the medicine and the doctor changed me to Amoxicillin 3x day for 5 days. I took the entire medicine and felt as though I had morning sickness all day long…ugh! After another urine culture, I was told that the bacteria was still present. It’s supposedly a non specific bacteria. I have a history of drug allergies and have had 3 anaphlaxis reactions in the last 10 years. I was then prescribed Cipro, which after reading the handout, I REFUSE to take. I am fed up with antibiotics and allergic reactions. I need some advise and guidance in what will take this away. I took an AZO strip test and it showed no nitrites and only a very minimal amount of white blood cells. Any advice or comments are welcome. DESPERATE to get this taken care of WITHOUT antibiotics or allergic reactions.
Good for you for not taking The cipro. It has ruined my life and many others. I was recently prescribed bactrim. Did you find help?
You might have Interstitial Cystitis (IC) – it still causes white blood cells to appear in the blood but urine sample culture won’t turn up any bacterial infection. This happened to me for years before I was referred to a urologist and properly diagnosed. If you didn’t have any symptoms pre-doctor’s visit then it probably wasn’t a UTI (you’d know something was up).