UTIs can be caused by poor hygiene, impaired immune function, the overuse of antibiotics, the use of spermicides, and sexual intercourse. The most common cause, accounting for about 90 percent of all cases, is the transfer of Escherichia coli bacteria from the intestinal tract to the urinary tract.
For those of you who have experienced a UTI, there isn’t much you wouldn’t do to avoid another one. While I personally have never had a UTI, my patients have told me how symptoms like pain, burning, nausea, and even bloody urine can be debilitating, and for those who get chronic UTIs, the fear of infection can be enough to prevent engagement in any activities that could trigger one. For people who get them frequently, sometimes a specific cause cannot even be pinpointed. This can be frustrating and scary.
Fortunately, there are a few methods of natural UTI treatment and prevention that have worked extremely well for my patients, to the point where they no longer worry about getting a UTI.
These treatments don’t require a prescription, are inexpensive, and are completely drug-free. While your doctor may not know about them, I hope this article will help you completely avoid UTIs—or at least significantly reduce their frequency and severity. I recommend working with a Functional Medicine practitioner who is focused on treating the root cause of your UTIs.
UTIs can be debilitating, but it is possible to get relief without requiring a prescription. Check out this article for five ways to cure UTIs without antibiotics. #functionalmedicine #wellness #chriskresser
What Is the Standard Treatment for a UTI?
Doctors typically use antibiotics to treat UTIs, and the type and duration depend on your health condition and the type of bacterium found in your urine. (2) Commonly prescribed antibiotics are:
- Trimethoprim/sulfamethoxazole (Bactrim)
- Amoxicillin
- Ampicillin
- Ciprofloxacin (Cipro)
These antibiotics are often unnecessary and may cause more problems in the future by destroying the beneficial bacteria that prevent pathogenic bacteria from growing. Long-term use of antibiotics can also lead to antibiotic resistance in strains of bacteria like E. coli in the gut, and a UTI caused by these bacteria will be even more challenging to eliminate and can cause more serious issues like a kidney or bladder infection.
Furthermore, antibiotics do very little to prevent the infection from happening in the first place. So, while drugs may be an easy fix for the short term, in the long run, you will continue to be susceptible to UTIs, and these infections may be worse than if you had never taken a course of antibiotics in the first place!

Curing and Preventing UTIs Naturally: D-Mannose
Treating UTIs with D-Mannose
D-mannose is by far the most effective supplement for both treatment and prevention of UTIs. Similar to glucose in structure, D-mannose is a naturally occurring sugar that is found in a number of fruits, including apples, blueberries, and cranberries. (3) This sugar is the reason that cranberry juice has been commonly recommended as a UTI treatment, though it is far easier to get the recommended dosage from a supplement. D-mannose is effective because it attaches to E. coli bacteria, causing them to stick to each other and preventing them from sticking to the walls of the urinary tract. (4) The bacteria can then easily be eliminated from the body during urination.
D-mannose, even in large quantities, does not cause any adverse effects, and cannot be metabolized the way other sugars can, meaning this supplement is safe for people with diabetes and others who are avoiding sugar for any reason. This treatment is also safe for children and the elderly.
Symptom relief can be seen as quickly as the following day, and most symptoms of UTI are generally resolved after 48 hours of treatment. Additionally, taking D-mannose during a time where you feel you are most prone to UTIs, such as before intercourse or during prolonged antibiotic treatment, can help prevent a UTI from ever developing in the first place. This is especially helpful for those who are prone to chronic UTIs and want to be able to engage in normal life activities without fear of infection.
The typical dose of D-mannose for UTI treatment is 500 mg, in capsule or powder form, taken with or in a glass of water or juice every two to three hours for five days. It is a good practice to continue taking the supplement even after symptoms have diminished to ensure complete elimination of the bacteria in the urinary tract. This dose can also be taken as a preventive, or prophylactic, method.
While there has not been any peer-reviewed research to support the effectiveness of D-mannose in treating or preventing UTIs, clinical and anecdotal experience suggests it is highly effective for the majority of infections, both acute and chronic. Some of my patients who have used D-mannose as a UTI treatment method have even described its effects as “miraculous”—so it’s definitely worth a shot!
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Four Alternative Treatments for Chronic UTIs
One caveat with D-mannose is that it is only effective with UTIs caused by E. coli infection. While this accounts for about 90 percent of cases, 10 percent will not benefit from this treatment. In this case, supplements that help disrupt biofilms can be useful in treating and preventing UTIs.
Biofilms are an accumulation of microorganisms and their extracellular products forming structured communities attached to a surface such as the lining of the urogenital tract. (5) The development of a biofilm can make infections extremely hard to treat, since they commonly return shortly after treatment is stopped.
The antibacterial resistance of pathogenic biofilms is one of the major reasons why those who get a UTI are highly susceptible to getting more in the future—if the biofilm is not completely eliminated, the infection will eventually return at some point.
1. InterFase Plus and Biofilm Defense
This is why the use of biofilm disruptors can be helpful for preventing the recurrence of chronic UTIs. The biofilm disruptors that I recommend to my patients are InterFase Plus from Klaire Labs or Biofilm Defense from Kirkman. These contain specialized enzymes to disrupt the biofilm matrix embedding potential of pathogens, and dissolve the sugar and fibrin components of most pathogenic biofilms. By destroying the biofilms, the recurrence of UTIs despite proper hygiene can be reduced. (6)
2. Lauricidin
Lauricidin is another supplement that may help in treating UTIs, particularly those that are caused by types of bacteria other than E. coli. Lauricidin (a proprietary form of monolaurin) has antiviral, antifungal, and antibacterial activity, and is specific against pathogenic bacteria so it won’t disrupt beneficial bacteria in the gut. It is highly effective at combating gram-positive bacteria in the families of: (7)
- Streptococcus
- Staphylococcus
- Corynebacterium
- Listeria
- Bacillus
- Clostridium
It works by disturbing the integrity of the bacterial cell membrane, blocking replication and making it easier for the immune system to destroy the pathogen. Lauricidin is only helpful, however, for UTIs not caused by E. coli, which is gram-negative and has a different kind of outer cell membrane than gram-positive bacteria.
3. Nattokinase
Nattokinase is another enzyme that has been shown to dissolve biofilms. (8) Produced by the bacteria found in the fermented food natto, this enzyme is proteolytic and can help break down the fibrin proteins that maintain the structure of biofilms.
Because of its fibrin-breaking ability, it’s important that nattokinase supplements are not taken by people with bleeding disorders, or by people who are taking Coumadin (warfarin), aspirin, or any other drug that influences blood clotting, unless supervised by a physician.
4. Apolactoferrin
Apolactoferrin (or lactoferrin) is one more supplement that I recommend to my patients with recurrent UTIs. This multifunctional protein lactoferrin is a component of the immune system with antimicrobial activity, and is part of the innate defense, found mainly in secretions and mucosal surfaces. (9)
Lactoferrin has been shown to block pathogenic biofilm development by binding to iron and causing the bacteria to “wander” across surfaces instead of forming cell clusters and biofilms. (10, 11) One study found that the amount of E. coli bacteria in the kidneys and bladder of mice was significantly reduced 24 hours after oral lactoferrin treatment, compared to a control group. (12) More research is necessary to demonstrate the effectiveness of lactoferrin in treating UTIs, but I believe it is worth trying, especially if dealing with chronic UTIs.
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So good to see UTIs being discussed and to acknowledge what a big issue they are for Women.
I have had UTIs for 10 years and was on a low dose antibiotic everyday for one year. Fortunately after a paleo diet and Dmannose I have had no problems for the past 2 years. Dmannose was a miracle for my UTIs.
However a year ago I got pregnant for the first time at 38. I continued to take low dose Dmannose most days. My baby died at 14 weeks. I see from the above discussion that Dmannose is not recommended while pregnant. My pharmacist and the Company website suggested it was safe in pregnancy. Never the less I will not be taking Dmannose as I try to get pregnant again. Unfortunately cranberry is not effective for me so I am back to antibiotics as the only effective treatment and see my health being compromised again…it’s a double edged sword.
Hi Chris,
I had my first UTI a week after I had sex for the first time. Then I got another one a month later, and another one a few months after that, most likely from sexual activity. Then my doctor told me to take one Cipro after sex. Eventually, I stopped taking them and just used them when I got a UTI as they would be prescribed. Eventually, I stopped getting sick. Then I got another one when I changed sexual partners, then another one after I changed sexual partners again. What would you recommend for me?
I get UTI’s after sex as well — it didn’t happen when I was younger, but started when I was about 45. Good hygiene before and after, as well as urinating afterward helps.
I’ve lately been able to control the issue by taking D-Mannose before and afterwards for a couple of days, but at a much stronger dose than 500 mg – 4 to 5g – 3x a day. I also have found that Solaray Caprylic acid helps disrupt the bacteria in combination with D-Mannose.
Here’s a link to a product called U.T. Vibrance that might work for some people, and gave me the idea to increase D-Mannose, because their recommended dose is 5g.
http://www.walgreens.com/store/c/vibrant-health-mannose-%26-botanicals-u.t.-vibrance,-tablets/ID=prod6179226-product
For those who get recurrent UTI’s, and you have Fibromyalgia, it may be related to that condition. Here’s a book with a chapter that goes into more detail as to why:
http://www.amazon.com/What-Your-Doctor-About-Fibromyalgia/dp/1455502715/ref=sr_1_1?ie=UTF8&qid=1410625290&sr=8-1&keywords=Dr.+Paul+St.+Amand
I have been tested positive for E.coli in the urine following sore bladder area and frequent urination.
I started taking D-mannose but it’s getting worse even though my symptoms already subsided over the last 2 days (before I knew it was a UTI).
I wonder why this is? I find if I drink more things get worse. I’m getting worried. Is there anything else that can be used for e.coli UTIs?
I’m considering Bentonite clay and/or Pau d’Arco tea as well as the D-Mannose.
thanks
My daughter suffered with what she thought was UTIs for years. Then we read about Pelvic Floor Dysfunction. She started treatment for PFD with a skilled physical therapist. Within four treatments, all of her symptoms went away and she has not had a “UTI” since then. When she starts to feel any kind of bladder discomfort, she goes in for a treatment. It never fails to relieve her symptoms. She now knows that she tends to get tension in her pelvic floor and it puts pressure on her bladder that feels like an infection. Her physical therapist says she has seen this situation many times. My husband is now getting PFD treatment for his chronic “prostatitis” and the results have been amazing. I highly recommend anyone with chronic UTI symptoms try this therapy.
Given that 20% of women will get a UTI, many during their reproductive years, and given that UTIs can develop into fatal kidney infections, either traditional societies had some effective treatment we’ve forgotten, or UTIs have become much more common than they used to be.
The third option would be that UTIs killed some high percentage of women for millennia prior to antibiotics, which would constitute a strong selective pressure.
Given that the bladder is not sterile (http://arstechnica.com/science/2014/05/urine-and-the-bladder-are-not-sterile-contain-bacteria/), I’d like to see some research into how to encourage a healthy, robust community in the bladder as a means of preventing UTIs.
what alternative treatment is there to treat uti from enterococcus faecalis.
I have been reading about this organism and it says something related to root canals. I used to have a root canal and then the crown fell off and it stayed uncovered for at least 2 months. Then I went and got the post removed and now there is no tooth there, but healing. Does this infection have anything to do with the tooth.
please help
I have an autoimmune disease of the bladder, and I frequently get bladder infections. Treating them without antibiotics became pretty crucial for me as I wanted to heal the autoimmune disease and protect my gut. Recently, I have come learn about homeopathy, and in particular the Banerji Protocols of homeopathy. I have successfully treated 2 bladder infections homeopathically. One was ecoli and the other was strep (as in the strep throat kind). I took Meddorhinum 200 every 3 hours when the pain was bad, then I gently backed off to 3 times a day then to twice. I had the guidance of a good homeopath. I highly recommend the Banerji protocols for various ailments, including bladder infections. I detail more info on my blog: WeAllSeeIC.blogspot.com
I hope this helps you.
PS in homeopathy, it matters not what kind of bacteria you have…you just take the remedy for the symptom…and in the case of the Banerji Protocols, you take the remedy for the general diagnosis (I.e. UTI, regardless of what kind if bacteria it is).
I started using D-Mannose May of 2009. I have gotten UTIs my whole life. I do have some reflux which causes the bacteria, but not bad enough for them to do surgery. So basically Ive had to deal with taking antibiotics for most of my life.
Also I was diagnosed with Intercistal Cystitus in April of 2008 and was in horrible pain. The cyctitus is caused by the bladder no longer having a lining on it. So anything you eat that is acidic can be incredibly painful, even debilitating. And I have a high pain tolerance.
A friend of mine that is an herbalist suggested I try D-Mannose. It took about a month for me to notice a difference. I took 1000 mlg 3 times a day initially. I now only take 2 in the morning and 1 at night. After a month I was no longer in pain and could eat what I wanted without worrying that it was going to cause me pain. Sex is also no longer an issue. Not only all that, but I haven’t had a UTI in 4 years! D-mannos has absolutly been a miracle drug for me! Ive suggested it to several others as well and they have also been amazed by the results.
I buy mine now thru Amazon. Solaray sells 120 tablets for 30.00. You can also get 60 tablets at The Vitamin Shoppe for 19.99.
I strongly suggest if you havent tried it. Do SO! D-Mannose gave me my life back!
Has anyone tried interfase for bio films? If so, how did it work? Mine finally came, but I am not sure how exactly to use it, or if it will have negative effects on good bacteria. I am desperate, but still unsure about how to use it.
Thanks.
My mom has had UTIs forever and everytime she was given antibiotics but they still came back. I bought the D-Mannose and she did the regime for the last episode and is now on the maitenance regime. Guess what? No more UTIs. I am taking the Lactoferrin for HepC but have found that it works on the UTIs as well. When my liver functions went helter skelter I think I got an UTI which actually caused pressure on my brain, kidneys etc. I thought I had a bump on my head but I swear it was from the UTI. Now all is good except for one item Once a day my urine comes out orange could it be bilirubins are too high. Last check up they were 2.2 and the doc has sent me to a GI for help. Any advice?
Have a few questions:
1)
2) In addition to D-Mannose with CranActin, we use QBC for biofilm issues, which is Quercitin, Bromelain, & Vit C. I recently came across a product (UTI-Stat with Proantinox Liquid Cleansing) that combines D-Mannose with Crannberry, Bromelain, & Vit C (Ascorbic Acid) plus FOS (but no Quercitin). I have now read that FOS (fructo-oligo-saccharide) is possibly not such a great idea, since it might feed rather than inhibit e-coli & yeast. Wondering if anyone is familiar with this product, FOS, or benefit of Quercitin in combatting UTIs or biofilm.
Oops, sent before I wrote the other question. If an infection has grown severe enough to be a bladder or kidney infection, is the D-Mannose dosing still 500 mg every 2-3 hrs? How long should that higher dose be followed? Do you just drop down to a maintenance dose (whatever that is) or taper off on some sort of regimented schedule for several more days? My mother is so frail that I need specifics on how long to go on the high dose & then precisely when to drop down & on what schedule of reduction. Cannot afford to let infection rebuild by accidentally not keeping the higher regimen long enough.
What do you think of using aloe vera powder instead of D mannose powder?
Hi Chris,
Sounds like my case is unique. I am pregnant (1st trimester) and was just told I have a bladder infection but not from E. Coli. Broup B strep was found in my urine culture. Should I try Lauricidin or one of the other biofilm treatments?
Biofilm is on the way, and I began lactoferrin yesterday. Is it safe long term, or is it only for short term use? Thank you for this informative site! It is a wealth of new information.
I am waiting for my biofilm defense t arrive, and in the meantime I added lactoferrin to my herbal regimen. Is lactoferrin for short term use, or is it safe long term? Thanks for your wonderful and informative site!
Hello cris, wanted your opinion. I self cath due to a spinal cord injury. Im currently batteling an ecoli infection that is unresponsive to Levaquin/marobid and now resophen(spelling?) I started the dmannose last night. my question is because I cath im just empting my bladder instead of the urine flowing thru the ureathra and in my logic flushing that part out. Am I wrong in my thinking/ or can this dmannose still be effective eventhough I cath myself? very frustrated and depressed..ive been hurt 25 years and never faced anything like this. thank u
I have had chronic uti symptoms for twelve years. I have tried everything mentioned except for the biofilm disrupters. Reading about them has given me some hope. I can’t go more than a few days without taking an antibiotic, for the last three years. When I have followed herbal regimens, they have not worked. Uti is miserable and expensive. It was scary to read about crazy episodes and dementia from uti! Why does that happen?
How often does Chris chime in on questions? It would be exceedingly helpful to know how many days should one continue the “treatment level” of D-Mannose after UTI symptoms are gone (no fever, no blood, no delerium) & already done 5 days of 500mg every 2-3 hrs. What is the next dose regimen & for how many days, until one backs down to a maintenance dose? My 87 yr old mother has had an indwelling catheter for over 2 yrs now & essentially is unable to move (all this as byproduct of adverse medication reaction) so that we do suppositories & BMs in bed thus must be extremely careful on fecal contamination. Because we’ve been so extra careful, we’ve nearly never had UTIs. One we did with antibiotics then learned of D-Mannose so caught the second quickly with very lose dose. Now, a year later, we just conquered a severe e-coli UTI with the treatment regimen that Chris described but then I’ve not known how to titrate down in a way that won’t accidentally set us back (U/A & CBC now negative for infection). I don’t want to make the mistake of keeping her on elevated doses too long as I realize that her body might acclimate & thus not be as responsive to D-Mannose whenever we might need it at a treatment level of dose (vs. maintenance level) in the future.
I have been using the treatment dosing you recommended of 500mg D-Mannose every 2-3 hrs on my ailing elderly mother, actually electing every 2 hrs because the UTI was so severe. You mentioned in the article to continue for a few days after symptoms are gone. Can you be more specific? How many days after symptoms are gone do I continue at the 2-3 hrs rate? Then how far do I drop down? Do I go back to her prior maintenance dose of 1000mg/day? Or do I need to taper off? I don’t want to make the mistake of letting the infection rebuild if it’s not entirely conquered… but I also don’t want to keep her at the extra high dose as it’s producing fierce abdominal pain from gas/bloating.
My mom is 82 with constant reoccurring UTIs. Since using the D-Mannose regime for the UTI we have changed to the maintenance schedule. First week 2 capsules next week we will try just one. The capsules are 500mg. It cured the UTI and the maintenance is working, NO UTI as of yet. It does work. She did not experience the bloating or pain so make sure your mom is drinking a big glass of water with each dose and continues drinking water. Dehydration may be causing the side effects. Get a colored bottle so she knows it’s hers and keep it filled with water. My mom took so many antibiotics they were no longer working and actually hurting her stomach – killing the good bacteria as well as the bad. It is working for use. Hope this helps!
I have been reading your great article on how to treat UTI without antibiotics. I am a 60 yr old male sufferer of UTI and has been using antibiotics prescribed by doctor but success has been limited. I read reviews by users of D-Hannose – most with good results. I am thinking of trying it myself. I have 2 questions: 1) should I use only pure or 100% d-hannose? Some products on the markets include other ingredients such as cranberry extract which your article said to avoid cranberry juice. 2) Is there any special diet or food I should avoid so that UTI does not recur or I need to take d-hannose daily (plus exercise good hygiene) to avoid UTI recurrence.
I learn that Cranberry juice is great to treat UTI as I got it quiet often special after bowel moment even I went to clean myself in the shower after each moment. How fast will the infection develope after once infected fr the bowel moment? I tried Cranberry juice I like the taste but if I drink more than one cup a day it gives me diarrhoea. Sometimes I drink a lot of water to clear the infection. Will it help by drink a lot of water?