RHR: What You Should Know About Histamine Intolerance
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RHR: What You Should Know About Histamine Intolerance

by Chris Kresser

Last updated on

Revolution Health Radio podcast, Chris Kresser

For most people, histamine is not a problem, but there are potential issues that can make it a problem for some people. If you make too much histamine or don't break it down properly, find out how you can get symptom relief.

A lot of my patients are curious about this. I’m not going to say that we’re seeing more of it, because I’m not sure if that’s actually true. I think the awareness of it is higher, so we’re paying more attention to it. It may also be true that we’re seeing more of it, and there are some reasons why that might be the case, which will be revealed as we go through this answer. We’ll go into the basics of what histamine is and then we’ll talk about why histamine might be a problem for some people. Then I’ll finally get around to discussing diet for histamine intolerance.

Note: The Prescript-Assist supplements discussed in this article are no longer available. Please click here to learn more about a substitute, the Daily Synbiotic from Seed.

In this episode, we cover:

4:03  What Chris ate for breakfast
6:20  What is histamine?
11:49  Why histamine might be a problem for some people
17:36  Recommended diet for histamine intolerance

Play

Steve Wright: Good morning, good afternoon, and good evening. You are listening to the Revolution Health Radio show. This show is brought to you by 14Four.me, the 14-day healthy lifestyle reset program. If you’re someone who’s trying to put all the pieces of great health together that Chris talks about—such as diet, sleep, movement, and stress—but can’t seem to make them fit in your lifestyle, well, number one, I totally understand; and number two, this program is for you. So go check out 14Four.me, Chris’ new lifestyle reset program. You’re listening to the Revolution Health Radio show. I’m your co-host, Steve Wright from SCDlifestyle.com. With me is integrative medical practitioner, healthy skeptic, and New York Times bestselling author, Chris Kresser. Chris, how you doing?

Chris Kresser: Hey, Steve. I’m good. How are you?

Steve Wright: I’m tuned up, man.

Chris Kresser: I hear that.

Steve Wright: I got a big old workout in today, and I just got energy.

Chris Kresser: All right. I’d like to see that. Yeah, I’m not there yet. I’m going to the gym after this. So hopefully, I’ll catch up with you.

Steve Wright: Are you guys getting hit by the polar vortex right now?

Chris Kresser: It definitely feels colder than normal here. There’s no doubt about that. I feel the fall setting in, which is cool. I like the fall. It’s my favorite season. But yeah, I’m having to make a little adjustment. Because up until I left last week—I spoke at the Weston A. Price conference this weekend on the acid-alkaline hypothesis. When I got on the plane, it was like 75 degrees. When I got off the plane in Indianapolis, it was not 75 degrees, definitely. I was like, “Oh yeah, I live in a little bubble called California, where the weather is really different than other places.” Then when I came back, it was actually fairly chilly as well.

Steve Wright: You said fall. And I just looked out on my deck, and there’s six inches of snow out there.

Chris Kresser: You’re like, “Hey buddy, that’s winter.”

Steve Wright: Yeah.

Chris Kresser: Well, it’s all good. I mean, it’s sunny and nice out, but it’s just a little chilly. I’m not complaining. Of course, I have nothing to complain about. It’s all good.

Steve Wright: So how was the talk?

Chris Kresser: The talk went well. It was fun. It was well-received. You know, it’s another one of those myths that just keep sticking around despite a lack of evidence that really supports it. If this is new to anyone listening, you can Google “Chris Kresser acid-alkaline.” There are a couple of blog posts that we wrote about that a while back. I’ll probably eventually record the talk as a screencast and make it available for free, because there’s more updated and a deeper level of information in the talk, because it was a 1-hour-and-15-minute presentation.

Steve Wright: Wow. So are you saying that your myth-busting power got even stronger?

Chris Kresser: Took it up to a new level. The live talks, I like to do that. Also, I make an effort to make it accessible and fun, so that people aren’t bored out of their mind listening to me talk for 1 hour and 15 minutes. It was good. And it was good that I saw Chris Masterjohn. I watched him and he did a whole day on fat-soluble vitamins, which was pretty cool. I caught a fair amount of that. Then we had a couple of meals together. It’s always good to catch up with him. So it was a nice time.

Steve Wright: Were you referring to him by his new nickname, Professor J?

Chris Kresser: The Professor?

Steve Wright: The Professor, okay.

Chris Kresser: Yeah, I was. And he’s settling into his new position. He likes it a lot. He’s super busy. You know, he had to prepare last-minute for a couple of classes he’s teaching. But it’s great. Great to see him getting that kind of position and recognition.

What Chris ate for breakfast

Steve Wright: Awesome. Before we dive into this week’s question, Chris, did you have anything for breakfast today?

Chris Kresser: It was pretty standard today, Steve. Nothing exciting. I had scrambled eggs, sauerkraut, and some bacon. Then I had some coffee with cream. What can I say?

Steve Wright: Gosh, Chris, I’m let down. I’m so sad.

Chris Kresser: I’ll try to do better next time. All right. We have a great question from Genevieve today. It’s about histamine, which I know is a hot topic. A lot of people want to know more about it. I think this is going to be a really helpful show for a lot of folks. Let’s give it a listen.

Genevieve: Hi. Just wondering what kind of diet you recommend most for histamine intolerance, because I know there’s a few out there. The typical low-histamine diet includes grains. I think The Low Histamine Chef limits animal protein. Then, of course, you have GAPS, which is full of nourishing foods, but many are high histamine. And that’s what kind of caused my problem to begin with, was the high-histamine foods on the GAPS diet. So I’m just wondering what you would recommend most to follow to try and heal it, if it can be healed, although I know sometimes it might be related to methylation. Thanks.

Chris Kresser: Thanks, Genevieve, for sending that in. As I said, this is definitely a hot topic. We receive a lot of questions about it. A lot of my patients are curious about it. I’m not going to say necessarily that we’re seeing more of it, because I’m not sure if that’s actually true. I think just the awareness of it is higher, so we’re paying more attention to it. It may also be true that we’re seeing more of it, and there are some reasons why that might be the case, which will be revealed as we go through this answer. But let’s talk a little bit about basics, and then we’ll go into—basics of what histamine is, and then we’ll talk about why histamine might be a problem for some people. Then I’ll finally get around to answering her actual question about the diet for histamine intolerance. But I think it’s important to kind of maybe correct some misconceptions and go over some of the basics before we do that.

Steve Wright: That sounds like a plan, man. What is histamine?

What is histamine?

Chris Kresser: Histamine is an organic nitrogen compound that’s involved in local immune response and systemic inflammatory responses. It regulates physiological function in the gut and it acts as a neurotransmitter. It’s produced by immune cells called basophils and eosinophils and also mast cells, all of which are typically involved in allergic responses, among other things. To bring this home, if you’ve ever been stung by a bee or bitten by a mosquito and you see the redness and swelling there, that’s histamine-mediated. So everyone’s had experience with histamine. What it does in the inflammatory response is increases the permeability of capillaries—which are the small blood vessels—to white blood cells and some proteins, so that those white blood cells can engage the pathogens or the toxin in the tissue. From a dietary perspective, histamine is derived from the amino acid histidine, which is found in many different foods, especially fermented foods. We’re going to talk more about that later. But it’s also produced by some of the species of bacteria found in our gut. That is actually one reason why it’s possible that histamine intolerance is on the rise, because of this profound shift that we’ve seen in our gut microbiota over the past several decades. So just as celiac disease and gluten intolerance is probably on the rise because of that, I think it’s at least plausible that other conditions, like histamine intolerance, might be on the rise because of that as well.

Steve Wright: When I think histamine, the first thing that comes to my mind is allergies. Is that a good association or are there a lot of other things going on? Because I know you used the bee analogy there.

Chris Kresser: It is a good association. Like I said, basophils, eosinophils, and mast cells are all very much involved in the allergic response, and histamine mediates that allergic response. The itchy eyes, watery eyes, itchy skin, all the things that you associate with allergy and atopy, those are definitely mediated by histamine. So if someone has a lot of allergies or they’re having kind of allergic responses that they don’t necessarily associate with any particular trigger, that could be an issue with histamine.

Steve Wright: When you say mediated, what does that mean?

Chris Kresser: It means that histamine is probably causing the symptom. The excess production or the inability to break down histamine is causing those symptoms. And it’s not just doing it to irritate you. Histamine actually, like I said, plays an important role. It increases the permeability of capillaries to white bloods cells, so that the white blood cells can do what they’re supposed to do and they can get there. So we need histamine. The problem isn’t histamine itself; it’s when people have problems breaking it down or they’re overproducing it. I do want to point out that this phrase we’re using of histamine intolerance, if you look it up in the scientific literature, you’ll find a couple of papers that talk about it, but it’s not a legitimate medical condition, like diabetes or something, that has a clear etiology and pathology, and a clear treatment. A lot of people will argue that histamine intolerance doesn’t exist and it’s imaginary. I think just like adrenal fatigue and some of the other things that we talk about, it’s true that it doesn’t exist as a distinct disease entity. But it’s also true, and there’s plenty of research to support this, that there can be problems with histamine breakdown. And if that’s the case, excess histamine can certainly cause symptoms, and that’s well-established. So we use the phrase “histamine intolerance” just as a colloquial way to talk about it. But just understand that if you go to doctor and start talking about histamine intolerance, they’re probably going to look at you strangely. There’s actually a new term that’s been proposed for this syndrome. It’s mast cell activation syndrome (MCAS), which we’re going to talk about in a second. There are a few papers that have been published about that. So if you want to impress your doctor with a fancy term and show him/her some scientific papers that support this, you can bust out the MCAS term. All right.

Steve Wright: Just dropping it!

Chris Kresser: So I’ve mentioned that the real issue with histamine is—well, let’s go back to the background. Once histamine is produced, it’s broken down by two primary enzymes. One is histamine N-methyltransferase, and the second is diamine oxidase. For a long time, it was thought that diamine oxidase played the major role in breaking down histamine. And it probably does. But lately, there’s been a little bit more focus on histamine N-methyltransferase. If you recognize that term methyl, you know, we’ve been talking about methylation and methyl donors lately on the show. That’s another hot topic. They’re definitely related, which we’re going to discuss. So the key thing to understand here is that for most people, histamine is not a problem. Histamine is a normal part of the physiological response. If you get exposed to something, histamine can help the inflammatory reaction, and then the diamine oxidase or methyltransferase breaks it down. That’s the end of the story. You never need to think about histamine, it’s not an issue. That’s what’s true for most people. But there are potential issues that can make histamine a problem for some people.

Why histamine might be a problem for some people

The issues are broken into two categories. One would be overproduction, so making too much histamine. The second would be inability to break it down properly. Let’s look at each of these in turn. Overproduction typically would have two main causes. The first could be gut dysbiosis, because we know that certain types of bacteria produce histamine and certain types of bacteria degrade it. So if we have an overrepresentation of the kinds of bacteria that produce histamine, then you could theoretically have excess histamine production. That could cause some of these histamine intolerance issues that we’re talking about. The second cause is something called mast cell activation syndrome, which I just mentioned. This is still a relatively poorly understood entity. There was a paper. I think the first papers were published on it just a couple of years ago. There’s one kind of review paper in 2013. Basically, it involves an overactivation of mast cells, which are the cells that primarily produce histamine. We don’t really know what causes this. Certainly, genetics play a role. There are a lot of mutations that can affect mast cells and the production of histamine. But there are likely other causes that haven’t been well-defined at this point.

Steve Wright: Chris, how many mast cells do we have in our gut?

Chris Kresser: I don’t know the specific number, but there are lots of mast cells all throughout the body. The production and breakdown of histamine is particularly notable in the gut. This is why histamine intolerance can lead to gut issues, and disturbance in the microbiota can lead to excess production of histamine or inability to break it down. So speaking of inability to break it down, that’s the second major problem. That can be broken into three subcauses. One would be impaired methylation, because histamine N-methyltransferase requires methylation to function properly, that enzyme. So if you’re not methylating properly, you won’t break it down. Second, not enough histamine-degrading bacteria. So dysbiosis, again. The third reason would be a genetic issue with diamine oxidase production. Some people just genetically don’t make enough diamine oxidase to break down histamine. So those are the main problems with histamine and the causes of those problems.

I just want to point out, before I go to the symptoms, that there are other mutations and genes related to the methylation pathways that can cause histamine issues. One is monoamine oxidase (MAO). If you’ve done a 23andMe gene profile and then you’ve run it through Genetic Genie or MTHFR Support or something like that, if you look on there and you’re homozygous for MAO, then there’s a decent chance that you may be sensitive to histamine. So that’s something to be aware of. The symptoms of histamine intolerance are very similar to some of the symptoms of allergies. You have itching of the skin, eyes, ears, and nose; hives; tissue swelling, especially facial and oral tissues; a feeling of throat constriction or tightness; hypotension, like a drop in blood pressure, especially you get dizzy when you stand up quickly; tachycardia, so rapid heartbeat, increased pulse rate; palpitations; symptoms that kind of resemble anxiety or panic attack; chest pain; nasal congestion; runny nose; seasonal allergies; conjunctivitis, which is irritated, watery, reddened eyes; some types of headache, like migraine can be related to histamine; fatigue; confusion; irritability; digestive upset, especially heartburn and reflux; and much more rarely, occasional loss of consciousness, blacking out just for a few seconds that’s unexplained by other causes.

Steve Wright: So Chris, that’s like a list of symptoms that if we stack them on like a severity scale, goes from annoying to life-threatening.

Chris Kresser: Yes.

Steve Wright: Would it be safe to assume that the lower you are maybe on your health ladder, the more this could be an issue for you? And as you sort of have more things in balance as far as health-wise, maybe histamine issues are going to be more on that annoyance scale?

Chris Kresser: I think the health status is one factor that determines sensitivity. But there are other factors that don’t necessarily relate to current health status, which are genetic. So if somebody has homozygous MAO mutation and they’re also homozygous for MTHFR mutation and they have very poor methylation because of that, and then they also have a defect in diamine oxidase, an inability to break down histamine once it’s produced, and then maybe they even have defects that lead to overactivation of mast cells and production of histamine, that person’s probably going to be pretty sensitive to histamine even if they’ve got everything dialed in. I don’t know how many of those people there are that have that unique constellation of things together; probably not that many. But they may always need to be careful, for example, with fermented foods, and some of the foods that we’re going to talk about that are high in histidine, and therefore, histamine. And/or they may need to use some natural antihistamine support or take some diamine oxidase as a treatment.

Recommended diet for histamine intolerance

Now, let’s talk about the low-histamine diet, because this is something that can be really helpful symptomatically. Of course, for longer-term healing, you want to address the underlying cause and things like that, dysbiosis or methylation problems, but the diet is an important part of the treatment always and getting some symptom relief. Fermented food, as I mentioned, is the biggest offender. That’s because the bacteria during the fermentation process produce histamine. So things like wine, cheese, yogurt, kefir, vinegar, all of which are healthy foods otherwise, are like kryptonite for people who have serious histamine intolerance. I’ve often had patients come and say, “God…” They’ll fill out the diet survey and they’ll mention something about how they’re intolerant of these things. It’s kind of a revelation for them to learn about histamine, because they’d never been able to figure out what the common thread is between all of these foods that they’re reacting to. Seafood, unfortunately—I say unfortunately because it’s such a healthy food, and it’s underrepresented already in many people’s diets—but seafood, shellfish, finfish, fresh, particularly smoked or canned seafood, is also really problematic from a histamine perspective. Eggs; processed, cured, smoked, and fermented meats like bacon, sausage, salami, pepperoni; leftover meat, because after meat is cooked, the histamine levels increase due to microbial action as the meat sits; all fermented milk products, of course; citrus fruits; berries; dried fruit; spinach; tomatoes; artificial food colors and preservatives; certain spices like cinnamon, chili powder, cloves; herbal teas; alcohol; chocolate; cocoa; and then vinegar and foods containing vinegar, such as pickles, relishes, ketchup, and prepared mustard.

Steve Wright: No wine, no pickles, and no chocolate. We have to help these people.

Chris Kresser: Sorry, I just removed all of your favorite foods. Don’t hate me. It’s not my fault. I didn’t make this stuff up. If you didn’t get that down and you’re listening to this in your car, don’t worry about it. If you Google “Chris Kresser histamine,” you’ll see a blog post that has this list. Also, don’t freak out if you have to remove these foods for a period of time to feel better. Because in most cases, when you do address the underlying causes—like the gut dysbiosis and methylation—then most people are able to add some of these foods back in without any ill effects. Now I do want to point out that there’s a huge spectrum in terms of histamine intolerance. You were probably hinting at this, Steve. But there are some people who, red wine, they can’t tolerate. But almost everything else on this list, they do okay with. Then there are people on the far end of the other spectrum—and there are a lot fewer of these, but I’ve had some patients who fit this profile—who, the only meat they can tolerate is meat that’s literally been slaughtered. Like, they have to go to the farm right after it’s been slaughtered and get it, because if the meat even sits for a little bit, the time that it takes to get to the store and sit in the meat case at the store, it’s already got more histamine that they can tolerate. A couple of my patients have had to go on almost like a completely plant-based diet, because all of the animal products, they haven’t been able to tolerate. Over time, fortunately, that changed a little bit for them. And they were among the sicker patients that I had. So again, like I said, it’s not very common. But just know that there’s a big spectrum, and you need to really experiment a lot with this stuff to figure out what works for you and what doesn’t work for you.

Steve Wright: I think Chris points this out in the article, but if we have anything that can help you with that, just remove it all at once. Just remove it all at once. Just take the pain. If you think of it as painful to get rid of some of these foods, which I’m sure some people do, just do it all at once. Don’t just mess around and say, “Okay, I won’t do wine for a little while or chocolate for a little while,” because you’re not going to figure it out.

Chris Kresser: That’s never going to get you anywhere. That’s a great point. You have to just suck it up, take it all out, and then start adding stuff back in one by one. That’s the only way to do it. It’s really laborious, but it works. And both Steve and I know this from experience, working with a lot of people. You can get your diamine oxidase levels tested actually. It’s a serum test. So you can get diamine oxidase. You can get serum histamine tested. Serum tryptase, T-R-Y-P-T-A-S-E, is considered one of the most sensitive markers for mast cell activation syndrome. So you can run some tests, and that might be helpful in seeing where the problem lies. For example, if you run the test and your diamine oxidase levels are normal but your histamine is very high, that means that you may not have an issue with breaking down histamine. It may be more of an issue of overproduction of histamine due to gut dysbiosis, for example. In that case, fixing the gut and doing a low-histamine diet would probably be enough, without any additional intervention. However, if you get tested and your histamine levels are normal, but your diamine oxidase is really low, then that suggests you have possibly a genetic deficiency of diamine oxidase. And what’s probably going to help you more is to take diamine oxidase, which you can take as a supplement. Seeking Health sells it as Histamine Block. There’s also DAOSin, D-A-O-S-I-N, from Swanson. There’s Histame. They’re all basically the same thing. It’s actually taking diamine oxidase, the enzyme that breaks down histamine. You take it with meals. That can help a lot. Then there are some natural antihistamines that are probably a better idea for excess histamine production. Those include quercetin; bromelain, which is an enzyme; pine bark extract, which is also known as Pycnogenol. That’s pretty expensive, but it can be effective. Then there are, as I said, certain species of bacteria that break down histamine and certain species of bacteria that produce histamine. So Lactobacillus casei, Lactobacillus delbrueckii, and Lactobacillus bulgaricus, which are typically in yogurt and fermented dairy products, those are notorious histamine producers, which is why fermented dairy can be like kryptonite. Lactobacillus plantarum and Bifidobacterium infantis are two histamine degraders. It’s quite difficult though to get Bifidobacterium infantis separately as an individual strain, without other strains that are also in it. But it is possible to get Lactobacillus plantarum that way, just as a single strain, pretty easily. So that can be a good one to take. Then soil-based organisms like Prescript-Assist, which I like for many other reasons. This is another reason that I like it. There’s not a lot of research on this, but my experience is that soil-based organisms tend to be neutral or even histamine-degrading. They tend to be tolerated pretty well by people with histamine issues. That’s it, Steve. I hope that was helpful, Genevieve, and that we answered your question.

Steve Wright: Nuh-uh. I’m not letting you off the hook just yet, Chris.

Chris Kresser: All right.

Steve Wright: I have one question here to follow that up. So that was all, like, at the mast cell level. But the mast cells and everything we’re talking about here is part of—the inflammation pathway is part of the immune system. And I feel like this podcast would not be complete with at least a couple minutes about me asking, is there some play here with maybe improving your hormone levels, maybe your anti-inflammatory hormones—cortisol, for instance, if you’re having adrenal issues—something like that, that would be part of this whole equation as well, that people with histamine intolerance could get lost in the forest?

Chris Kresser: Yeah. No doubt, Steve. The reality is, we do these 25-minute shows—or 30 minutes—and we focus on a single topic. But that’s never really how it works in practice, right? There’s always a person that’s attached to one of these topics, and they don’t just have histamine intolerance. They have several other issues: adrenal fatigue, autoimmune disease, and whatnot. Certainly, all of those things have to be addressed for a successful outcome. It’s a great question. It’s true that mast cells, basophils, and eosinophils are part of the immune system. And if you have a hyperactive or underactive or swinging between hyperactive and underactive immune system, then that is going to exacerbate the problem. If you have high cortisol, low cortisol or inappropriate production of cortisol throughout the day, that’s going to cause an inflammatory response and affect probably histamine production in different ways. Certainly, imbalances of sex hormones can affect that. And as we mentioned, dysbiosis, but also several other gut issues. So SIBO and parasites and intestinal permeability and all of the potential things that can go wrong can affect it. There are probably the things that we’re not even thinking about at this point that can affect it as well. So certainly, you need to always consider the entire picture. But I can say with some confidence that the things that we’ve talked about in this show are probably the most important from the histamine perspective, and will give at least some relief while you’re working on those other bigger picture concerns.

Steve Wright: Awesome. Thanks for wrapping that up and bringing it back up to the top.

Chris Kresser: Sure. Good question. A couple of announcements. The paperback version of my book is coming out on December 30th at the end of this year. It’s been renamed as The Paleo Cure instead of Your Personal Paleo Code, which is the hardcover title. There are a number of reasons behind that, which I’ll talk about on a later show. But it’s the same book, just a different cover, different name. We’re going to be doing some cool stuff around the book launch in December, so keep an eye out for that. We’ll be back with some more details. 14Four has been just a blast to see how many people have signed up. I think almost 2,000 people have signed up. Lots of folks are well into their 14-day reboot now. They’ve been through the preparation phase, and they’re starting. They’re having a great experience with it. We’re getting incredible feedback. There’s just a ton of activity in the Facebook group and community building around it. It’s just really exciting for me to see that this is really hitting in the way that I wanted it to hit. I know, from my own experience and from working with so many people, that it’s not really about information. Like, a lot of people know what to do at this point. It’s just about implementing it in your life. That’s the hard part. And that’s really what 14Four is about. So it’s just really—I’m excited to see the success that people are having and putting all these things together. If you haven’t checked it out yet, it’s 14Four.me. Keep the questions coming. We’ll talk to you. We’ll be back next week.

Steve Wright: Thanks, everyone, for listening. In-between episodes, if you’re wondering what Chris is researching—when he’s preparing for these episodes and his blog posts, a lot of times, he’s posting new things that he’s discovering on Facebook and Twitter. So if you’re not, I would encourage you to go over to Facebook.com/ChrisKresserLAc and Twitter.com/ChrisKresser to get updated ideas and things that he’s working on and things that he’s found. Thanks for listening. We’ll see you on the next show.

Chris Kresser: Thanks, everyone. Bye-bye.

101 Comments

Join the conversation

  1. Do nuts contain high levels of histamine? I realize that nuts are not listed on your list of foods to avoid, but they are mentioned on other lists online. Just want to make sure I do the histamine elimination diet correctly.

  2. Does anyone have any information about heat insensitivity (high heat of summer)? Our autistic son does have a yeast overgrowth (Candida glabrata), but always had normal stools, appetite, etc., growing up – but was sensitive to heat and lost some ability to self-regulate temperature after a high fever at 2 yo. He is 39 now. We trace the yeast overgrowth to HBOT/40 sessions back in 2002 (killed the beneficial anaerobes?)

    Thanks for any input you may have.

  3. I suspect histamine intolerance for my husband, and I think it’s from overgrowth of histamine producing bacteria. He has Celiac Disease, and he used to have a problem where he would randomly vomit (cyclic vomiting syndrome).

    I suspected SIBO, and he tried the GAPS/SCD, but it wasn’t helping. The only thing that somewhat helped (but not enough) was a low FODMAP diet. I finally convinced our family doctor (last year) to prescribe Rifaximin. He used to throw up every few months, then it became weeks, then it was days, and eventually nearly every day (it got BAD). The Rifaximin worked! No more puking! All kinds of other symptoms improved, including a constant plugged nose, swollen joints (similar to gout), GERD, and his asthma even disappeared! But then symptoms slowly began creeping back. A low FODMAP diet seems to help the most, but again, it’s not enough.

    I can’t convince him to do a low histamine diet (he said he would rather just cut out his tongue and die), so I had him start taking Quercetin, Pycnogenol, as well as Lactobacillus Plantarum. But now he’s getting really freaky coloured stools. It started clay/white, then yellow, green, and eventually a dark brown/black. Does anyone know if this is normal?

    • I would start small with the low histamine diet. Remind him it is a low (not no) histamine diet. Even a little removal of food histamines could help him. Start with freezing meat after it’s been cooked, not eating any leftover meat and maybe not eating fish or seafood. That should be pretty easy to do and should really reduce histamines. I had help with cromolyn sodium when I was first starting out and now dont really need to take it unless I know im eating higher histamines (like at a restaurant). Good luck.

      • We never eat fish/seafood because it’s so expensive. As for meat, rarely do we have leftovers (he eats it all). That’s the thing… he has a MASSIVE appetite. He’s 6’2″ and about 310 lbs now. I told him that wine (especially red) has high histamines, but he continues to drink about 3/4 of a bottle a night. He’s not drunk, but just likes his wine (he brews it himself). He will not budge. He said he already previously did the GAPS and whatever before, but never wants to do a diet again. He is already mad he can’t eat gluten (he does stick to that, though).

        I’m really just hoping to find out if his weird coloured stools is normal. Should I continue to give him the L Plantarum? Or should I cut back on it? Or give more? It’s Probiata brand and 15 billion per capsule.

        • Not sure what to tell you about the stools. I have never tried L Plantarum. I would talk to your dr. about taking digestive enzymes (Thorne BPP is the one I took while dealing with SIBO). I would also have him talk to his dr. about cromolyn sodium or DAO enzyme supplements if he isn’t willing to change his diet – it could help. I had to stop drinking wine for a few years because it made me sick even to have a tiny amount (vomiting, nausea, headache, severe heart palpations for a whole day or more after) I can have a glass every once in a while and be fine now that I watch my diet. Wine is a big one for histamines. 🙁

    • I’ve heard that when you do colonics you can shed a layer of built up crud. If I was in this situation I’d continue if it seemed to be producing good quality bowel movements and no actually known negative side effects. Just a guess but I think a good idea. Remember what took a long time to screw up likely takes a long time to reverse.

  4. Hi Chris,

    Sir Henry Dale inferred that eosinophils may produce histamine (PMID: 18877329). His inference, alas, was probably mistaken. At least regarding human eosinophils:

    https://www.researchgate.net/publication/7462086_A_heretofore_undisclosed_crux_of_Eosinophilia-Myalgia_Syndrome_Compromised_histamine_degradation

    Your readers might also appreciate learning that ascorbic acid (vitamin C) is a very potent ‘antihistaminic.’ The latter finding is well-documented.

    Best regards.

  5. Hey chris,

    Out of the options you listed (quercetin, bromelain, pycnogenol…I also heard grape seed extract is good), which typically works the best. Is pycnogenol something that can be used indefinitely at 100 mg (assuming you cannot fix the reason you have a histamine problem)?

    • It is my understanding that the dosage of pycnogenol daily depends on one’s body weight,

      If you weigh 150 pounds, you would need to take 150mg per day.

      It also looks to have an additive (not synergetic) effect when used with HBOT to clear candida. (Sort of like taking a drug and then going into a hot tub – into circulation faster is not always a good thing.)

      Google: “HBOT candida” and “Pycnogenol candida”.

      Die-off herx from candida – have Benadryl AND Zantac on hand = H1 and H2 blockers just in case.

      High(ish) doses of VCO can = herx candida die-off response. It is the caprylic acid in it that is key.

      The “active ingredient in Axona” = medicinal food for AD is caprylic acid which is one of the nutrients in VCO – saturated medium chain fatty acids that are actually GOOD for us.

      Think about this – alpha beta peptide in Alzheimer’s:

      “Furthermore, AB peptide exhibits antimicrobial activity and shows particularly strong inhibitory activity against Candida albicans.”

      http://www.nature.com/articles/srep15015

      From a probiotic standpoint…look closely at
      L. reuteri together with L. rhamnosus in various formulations.

      Methylation inhibited by Candida’s toxin. Undermethylated = high histamine.

      Candida triggers histamine release.

      Too many of us have excessive candida due to abx + steroid use + genetic predisposition to higher cortisol = glucose too high for too long (kidney CYP3A4) = stage set for candida overgrowth, diabetes, etc.

      Cu and Zn goes up and CoQ10 down with a high candida situation. CoQ10 down = mitochondrial dysfunction.

      Candida triggers IL-17 which impacts elastase (destroys our lung elastin). Normally alpha 1 antitrypsin can come to the rescue (inhibits elastase released), but there is an inverse relationship between cortisol and alpha 1 antitrypsin…levels of both can be genetically determined.

      Candida “steals” our Zn….bigtime.

      Candida’s toxin is acetylaldehyde and it impacts methionine synthase in the liver.

      Acetylaldehyde = migraine. To counter, low dose ginger can help.

      Ancora Imparo.

  6. I have very high levels of histamine and have been working for the last month to get them down with diet and an allergy drug called cromolyn sodium. I have been noticing improvement when my diet is very low histamine. One major symptom I have that no one seems to mention is excessive phlegm production. After I eat, especially at restaurants, the phlegm in my throat is severe. Does anyone else experience this? Do you think this is a key to the underlying cause of my histamine intolerance? My genetic test shows that I am heterozygus for MTHFR, MAO and DAO. Thinking of trying DAO enzymes to see if I get greater improvement. I also wanted to mention that I got a microdermabraision facial (tiny diamonds that exfoliate the skin) and my skin freaked out and I got an itchy rash on my face and back of my neck that lasted over a week and my neck is still pretty itchy. I am almost certain it flooded my system with histamines and put me way over my limit, so would caution anyone that suspects histamine intolerance that is thinking of doing microderm.

    • The phlegm is a histamine response to something you ate. For me, it’s usually the first sign that other events are going to follow (headache, “gunky” eyes, intestinal distress, etc.). In restaurants, I have a very limited list of food items that I can tolerate and I always ask that the food be fresh-cooked. I hope this helps.

    • Yes, I have the very same reaction. It seems like it doesn’t matter what I eat, I get phlegm (and I am a very healthy eater). I also have to take a small dosage of antihistamine every day or I start itching everywhere — even the inside of my ears! This is the first I’ve heard of mast cells and histamine overproduction — thinking this might be my problem! Can a normal doctor administer these tests?

  7. Wow how interesting our bodies are!!
    I have had intolerances since 1998 gluten,dairy.The past 5 yrs have suffered with my skin,mainly hands split and sore.After a radical hysterectomy in 2013 also removal of omentun,lymph nodes, apendix and sessions of chemo which killed everything good and bad.?Few months later skin problems got worse on hands chest especially face and my lips swelled up after eating melon,docs just wanted to throw cream and tablets at me which didnt help,no supprise there!!
    So i turned to a naturapath who got me off the sugar which was hard enough,but then it went on to foods like root veg(as of the high sugar content.Now i have problems with hystamine foods not that i have been diagnosed yet.Its
    difficult when nhs docs dont seem to be that bothered.
    I do hope i can resolve it soon.Its crap when you dont know if the next thing you eat will set it off.
    So im doing a low histarmine diet see if it helps

    Thanks everybody for all the info

  8. It seems like all of my problems began once I started going through menopause. Can menopause make my symptoms worse? Everytime I eat I feel like my throat is closing off. I have lost over 30 lbs and I can’t find anything to eat that doesn’t bother me. Is this truly hiatamine intolerance? I need help!

    • It’s very common in peri menopause and menopause. Best thing is to monitor your diet- histimine free. Estrogen & histimine are very connected.
      I get swollen throat and lips…it sucks:(

      • Hi there all!
        I’ve been going through similar problems since 1998.
        Intolerances to grains,dairy.
        2013 i started to get patches of excema again (previously had it on my face which went away).
        In that year I was diagnosed with ovarian cancer, so opted for a radical hysterectomy plus a bout of chemotherapy.
        Well of course excema cleared up as we know chemo kills all good &bad!
        After a few month of what I thought I was getting my life back together again.I started to get swollen split skin on my hands a month or so later had a bad reaction to melon lips swelled up so painful never went down prorperly till March time.
        In that time I had itchy flakey sores on face chest arms &hands.After numerous trips to the docs which were fruitless I visited a naturopath who got me on the road to recovery, she basically saved my life as by then after all the cancer ect I was at my wit’s end.
        I changed my docs & still going through the motions of the NHS. But I do find it very difficult to eat hystermine foods.I’ve asked for tests but no joy as yet!just skin patch tests through dermatologists who didn’t listen to me &tested me what was going on the skin &not what was going in the body,they were just ticking boxes.
        So I’m still reacting to all sorts of foods and still none the wiser!!
        Can anyone suggest a test I could ask the doctor for?
        Many thanks

        Lesley

  9. Fantastic information Chris, I have severe mast cell activation syndrome that has dramatically changed my life in the past year. One thing I noticed that was incorrect in this conversation was regarding tryptase. It is now understood that tryptase is a great marker of overall mast cell burden/load but it does not reflect the mast cell state of activation. So it is a useful test for Mastocytosis where the mast cells have proliferated but will nearly Always be normal in mast cell activation syndrome. It’s a common misconception that is made. For MCAS you can test urine prostaglandin, histamine and heparin. Dr Afrin has fantastic guidelines.

    • i noticed that as well fighting with my immunologist on this very point my tryptase was normal so I am to he says even with the mast cell masses that turn red and itch, the intestinal involvement and many other symptoms. I told him the pgd2 in urine and serum were better markers from my research to test for just the activation and not mastocytosis (glad that was negative).

  10. long-term migraine sufferer who has just been introduced to the idea that histamine is causing some of my migraines – now need to find out as much as I can. Am getting very confused with the conflicting advice regarding probiotics, and foods that are high in histamine. Any help would be great.

    • long-term migraine sufferer who has just been introduced to the idea that histamine is causing some of my migraines – now need to find out as much as I can. Am getting very confused with the conflicting advice regarding probiotics, and foods that are high in histamine. Any help would be great.
      I can relate to this comment.

      • The best advice I was given was to stop stressing about it. 🙂 Just pick a list (any list) and stick to it as best as possible. Reminder – it is a LOW histamine diet not NO histamine. ALL food has histamine. You are just trying to keep your overall levels low. As for probiotics, I have had great success adding in Seeking Health’s Probiota Bifido (also take Saccharomyces Boulardii, and Prescript Assist). I wish I had added the Bifido years ago. I think most of this is trial and error though because everyone is different.

  11. You state here that Lactobacillus plantarum breaks down histamine, but in a 2013 interview on histamine you state it produces histamine. I’m breastfeeding and have the most horrific allergies of my life, so I am desperate to do anything I can naturally that will help. Can you please clarify?
    Also, are pine bark extract, bromelain and quercetin ok to take while breastfeeding?

    • It’s just more complex than Bacteria X is good (degrades histamine), bad (produces histamine) or neutral (no noticeable changes in histamine levels).
      For each Bacteria there are many different strains and different behaviours for each strains. For example Lactobacillus casei have many strains (see https://microbewiki.kenyon.edu/index.php/Lactobacillus_casei) and, quite ironically considering the fact that L.Casei is often tagged as “histamine producer” most of L.Casei strains degrade histamine.

    • This podcast gives you good information, and it should help you to figure out what is wrong. Diet has to be individualized, and histamine intolerance is many-faceted.

      I know for me, what I had been convinced was HI turned out to be many food sensitivities resulting from leaky gut.

      I don’t understand your ungrateful attitude.

  12. My histamine reaction was caused by taking a supplement that is supposed to heal leaky gut. When I stopped taking the supplement, the histamine reaction went away.

    • Great for you.

      But a bit useless if you don’t tell us which particular supplement was involved in your histamine intolerance…

  13. My histamine intolerance gets much better when I take antibiotics- almost disappears. Does that mean that its not MCAD, but rather dysbiosis-caused?

    Thanks so much, to anyone that knows the answer.

    • My symptoms disappear (after first getting really bad) when taking antibiotics.

      For the last two to three years no doctor has been able to tell me what has caused all of the terrible symptoms I’ve had, particularly why I felt fine on antibiotics. I’ve been told repeatedly that it’s psychological. This has bugged me ever so certainly, as my quality of life is very poor because of the state of my health, and it’s difficult knowing that antibiotics cured me while I was taking them.

      Amongst a plethora of other symptoms, I get terrible migraines, brain fog, tight throat, enlarged glands in the throat, tight back of the neck (top of the spine), general fatigue. All of these were cured, short term, by antibiotics.

      Fortunately my partner is a Doctor, and has worked hard to try to find the cause of the problem, and histamine intolerance, as well as salyscilates fit the symptoms perfectly. I’m now embarking on a low histamine and low salyscilates diet.

      It’s nice to know I’m not going mad!

  14. Thank you for all the information! I’ve seen it mentioned on Alison Vickery’s site that you’re a proponent of FMT in treating histamine intolerance. In your practice how many transplants do you suggest for those undertaking FMT as part of their treatment of histamine intolerance?

    Thank you!

  15. I am only sensitive to fermented foods and beef bone broth. They both gave me diarrhea which is not a symptom of histamine intolerance. I wonder if I do have issues with histamine, but I do know that I’m sensitive to FODMAP. For that, I don’t have diarrhea but gas. So difficult to figure out what’s wrong in the gut!!!

  16. What are the supplements that can lower histamine release? I would like to see short-term results, but am willing to commit myself for the long run. Quercetin, Russian Choice Immune, Bifido probiotics strains in general, and mangosteen are the ones I found upon quick search. Does one of these work better than the others?

    I know that quercetin plays huge part in hormone by inhibiting aromatase. Is there any consensus on if mangosteen has any hormonal effect? If you have any other supplements that helped you greatly, please leave them in the comment. Thanks a lot.

    • Hi Changexpert…are you having some specific issues/reactions? Maxiflav brand quercetin supplements are what my ND gives me for the hives I had last year–two daily in the am before food. I also take courses of pharmaceutical quality probiotics. But those were only “supplements”–in the real sense. They were only helping my main goal of a complete diet/lifestyle over haul. Chris Kresser’s 14FOUR plan is what I just completed–and his plan, minus just a few minor histamine foods in the diet that I avoided, is pretty perfect for reducing histamine. It’s a great deal (I believe it’s $49 or something–and he gives exact meal plans, exercises–wonderful). If you can give me a little more info, I might have some more specific info for you. PS–I am not affiliated at all with Chris–I just believe after much research, he is one of the few practitioners out there who is giving real science based advice. Hope this helps!

      • Be careful with Quercetin – yes it does a great job on histamine, but it can also block COMT – so if you have polymorphism already, and your COMT is slow, this can really slow things down and increase estrogen, dopamine, and norep and ep – leading to being wired or anxious.

        • Yes – this! Quercitin is a big no for some – myself included (as well as the NAC supplement which horrifically increased my histamine)

  17. Wow this is a great interview. Thank you. Histamine issues are very common and most don’t realize that their health issues and genetic predispositions are somewhat embroiled in it. Some like me are already predisposed to it and need to know that it could be an issue too! For instance if you’ve done your 23andMe and Ancestry Gene tests, there are some genes that are Histamine and Mast Cell related. What you do is upload the Raw Data that you receive, into translation tools like Livewello which gives you results for all your genes.

    The App will then process your Raw Data from 23andMe, Ancestry and many other Genetics testing companies and give you results for these and thousands more. These are the genes:

    HNMT Gene: https://livewello.com/snps/library?action=preview&index=420933&for=demo

    EDS: https://livewello.com/snps/library?action=preview&index=204070&for=demo

    DAO Gene: https://livewello.com/snps/library?action=preview&index=431474&for=demo

    AOC1 & ABP1 Genes: https://livewello.com/snps/library?action=preview&index=600494&for=demo

    KIT Gene and Mast Cell Activation Disorder: https://livewello.com/snps/library?action=preview&index=811549&for=demo

    Links to some other Gene Tables: https://livewello.com/snps/library?author=ag9zfmxpdmV3ZWxsby1hcHByEwsSCldlYkFjY291bnQYkMTZAQw

    More info on how this works: https://www.facebook.com/notes/livewello/about-livewellos-gene-app/863565933654629

  18. It looks like fish and seafood are some of the worst food regarding histamine intolerance. Anyone knows if fish oil pills are okay?

    • So glad I found this website, I have been suffering from asthma like symptoms for 3years, I have done all the tests and have seen all the spcialist with no answers, I did find that taking benedryl as an antihistamine did seem to give me some relief, does that mean I could have a possible histamine intolerance? I would also like to know if fish oil pills would be OK to experiment with, I did take fish oils for about a week and on the 6th day I had sever breathing problems, but I also did clean mold off my windows that day as well, so I’m not sure whether or not it was a reaction to mold or my the fish oil, but I am somewhat scared to try again, not being able to breath is a scary feeling.

  19. I have cystitis symptoms when I eat soy drink coffee take vitamins and chemicals and fillers flare me too. Could I have too much histamine?

    Thank you,

    Deanna

  20. Oh my god, THANK YOU. You are such an amazing resource. For the past 15 years, I randomly get intense itchiness inside and around my nose and eyes. I’ve never been able to figure out what triggers it. Now I know what to look for. Plus, I immediately get muscle aches and a headache when I drink even a little wine. I had never even heard of histamine intolerance before, and had no idea those symptoms might be related. Thank you, and please keep sharing your wealth of information with the world!

  21. My daughter has struggled with Interstitial Cystitis for 3 1/2 years. She has tried Western medicine to no avail and is now venturing into the realm of functional medicine, but it’s so confusing to know what to try and in what order. We have wondered if histamine intolerance is at the root in her case, but there is also a family history of autoimmune disease. Chris, would you consider IC and how to treat it as a future podcast subject?

  22. As far as Genevieve’s question goes when it comes to diet…does anyone have any recommendations on grains or legumes. One reason I sort of strayed from the Low Histamine Chef website is because there are grains and legumes and I just got confused even though she explains why they are present. Especially since my dr suggested I look into GAPS to help with GI issues…it makes me wonder if GAPS is how you heal your gut and grains and legumes are def. NOT allowed do I just ignore gaps diet and follow the histamine diet recommendations?
    “The typical low-histamine diet includes grains. I think The Low Histamine Chef limits animal protein. Then, of course, you have GAPS, which is full of nourishing foods, but many are high histamine.”
    I guess I’m still a little confused on which direction to go…anyone’s suggestions or comments welcomed.

    • If you feel you need to avoid grains and legumes, I don’t see why you cannot follow a low histamine diet as well. I eat no grains at all, and recently decided to eliminate legumes for a time to see whether it made a difference for me. For starch I have been using plantains and various types of squash, instead of potatoes or sweet potatoes. You may be able to eat rice. I just eat many types of fresh and cooked greens and a variety of other vegetables, and some meat. If you are histamine intolerant, I’d say GAPS would not work for you because of the many high histamine foods. I had to give up broth, sauerkraut, and other fermented foods, at least for a while. But you should also pursue finding whatever is the root cause of the problem, whether low enzymes (and why), imbalance in gut flora, histamine food overload, whatever it may be.

      • I have been tested for SIBO in the past and that seems to have gotten better as it was a really mild case to begin with. I’ve recently emailed my Dr. to test DAO levels and other enzymes she feels necessary or anything else she thinks should be tested to get to the bottom of this. Symptoms are hives, facial redness, extreme facial redness when drinking alcohol, itchy spots etc…I really think there is something going on with histamines. Just wanting to get tested before I make the next step. I’ve been reading the GAPS book and learning a lot and had high hopes it would work but now…not so much.

        • Hey Lauren,

          Don’t give up hope! I think there’s a lot more people out there then you think who are battling the same thing, where multiple things are going on like SIBO, Candida, histamine intolerance. It’s a big puzzle for some people and for others it can be more of a simple fix. The GAPS diet and the Low Histamine Chef are great resources. I would also add in the low fodmap diet. The Whole 9 website has two great lists (low fodmap and histamine) that i found very helpful.

          http://whole9life.com/2013/06/expanded-iswf-shopping-lists/

    • Hi love, my earlier books included grains because I myself was still eating them at the time. The newest books only have a couple of recipes with rice, and a couple with pseudograins, and the newest will have no grains. My books chart the evolution of my diet and healing process, something that many of us go through. So people who aren’t yet ready to go totally grain free can buy the earlier books and take that same journey. My diet is gluten/grain and dairy free. I eat very fresh omega 3 rich fish several times a week (I know, controversial in the histamine world!) and I eat a little beef/lamb/duck once or twice a week. My approach is simple: be balanced, try to eliminate as few nutrient dense foods as possible, have a positive outlook on life generally. Meditate to switch off some of the mast cell/histamine/inflammatory genes (like the interleukins and COX) and do yoga to try and switch off some of the others (more on my blog). I’m really excited that so many of my readers are also healing – I really never imagined that I’d be able to inspire so many others to find an approach that works for them. My recipes feature SO many substitutions because I see them as inspiration…my personal approach won’t work for everyone, which is why I encourage people to explore all healing modalities and just take what works from each (including my own). Best of luck with everything xo

  23. Does anyone else experience breast tenderness and think it is related to histamine intolerance? I find my breasts get sore when I add bacon back into my diet. Would insomnia also be a symptom? I have read that histamines are stimulating to the nervous system. I took George’s “ALWAYS ACTIVE” Aloe and it was almost a miracle cure for some GI pain I was having. I read it has some action with mast cells…can anybody speak to this?

  24. Would breaking out in hives everytime I go running have something to do with histamine? I am active with hiking and working out, stairs, elliptical etc… But when I run my body gets extremely itchy and red. When I do anything else I’m fine.

  25. Hi Chris – you mentioned lab tests to look for histamine intolerance. What labs do you use for these particular tests? As a nutritionist there’s certain labs I could order for myself, or of course something like direct labs. I’m interested in getting these tests for myself if possible. Thank you!

    • Hiya, plasma histamine and diamine oxidase are often used by nutritionists, but are considered fairly unreliable as they fluctuate wildly. N-methylhistamine is more accurate. Prostaglandin d2, heparin and tryptase are ordered when mast cell involvement is suspected.

  26. Hi
    Just wondering if Chris or anyone else has had any experience with yakitron ( bovine liver extract) with histamine intolerance? My daughter and I both have histamine issues, and we have used a product called Anthrex (from standard process) which contains yakitron and seems to have made a big difference. We were doing other things at the same time though, so be interesting if anyone else has found it useful. thanks : )

    • I just got this product from my chiropractor and he swears it works for him if he starts the runny nose and eye symptoms after he eats something that bothers him, I tried it today after I ate something with small smoked bacon bits that I did not realizer was in the pasta salad and it helped me fast so I think it was the bovine liver that helped as I did not have the diamine oxidase I usually take if it happens for some reason it was not in my purse so I tried this new stuff and that was all I took.

  27. Endotoxin or LPS (lipopolysaccharide) from gram negative bacteria in the gut crossing into the bloodstream via leaky gut can foster hypersensitivity to histamine [Hinshaw, 1961. Pieroni, 1966.]

  28. Thanks for the great blog post!

    I still can’t eat tomatoes because they work like an intense caffeine shot. During the day it wasn’t bad at all, but sleeping was totally impossible. Warmed up food and vinegar are not as bad as tomatoes.

    Why do people react so differently to food with histamine even if the histamine content is similar or even higher than for other food?

    • Hi love, it’s a few reasons: histamine’s activity on the body differs depending on how much overall existing inflammation there is. Also because it depends what you’re eating it with – ie eating lots of anti-inflammatory or antihistamine foods (like bioflavonoid rich ones), could affect the overall inflammatory response. It depends on your level of enzymes, how much stress you’re under, and whether you believe the food is going to cause a reaction (read up on the amygdala fear response to foods, lots of great studies out there).

  29. Chris, you said, “Fermented food, as I mentioned, is the biggest offender. That’s because the bacteria during the fermentation process produce histamine.”

    What about resistant starch? Is histamine produced when RS is fermented in the gut?

    • That is so funny I had major histamine flare up following the FTA potato starch protocol. I wondered what mediated that response. the podcast is right I can react to any or all of the foods mentioned but it is much worse when I am stressed. the left over meat seems to be a particularly bad one. Quercetin really helps, and I found really reduced my hay fever symptoms this summer.

  30. I developed histamine intolerance after an unsuccessful three-month round of antibiotics, which was meant to treat me for Lyme disease. In my quest to heal my gut, post-antibiotic, I have had a very difficult time finding a probiotic that did not elicit an inflammatory response in my body. I attempted to take Prescript Assist in 1/4 capsule doses, but I had an allergic response to even that miniscule dose. However, I recently found a probiotic called Russian Choice Immune, that contains only Lactobacillus rhamnosus lysate powder (aka: the fragmented cell walls of l. rhamnosus). Apparently, this particular bacterium is effective at down-regulating histamine receptor genes in the body, and has anti-inflammatory effects throughout the gastrointestinal tract. If any of you with histamine intolerance are having a difficult time finding a “safe” probiotic, I highly recommend you check out this one! Russian Choice Immune is made by both the Nutricology and Allergy Research Group supplement companies. Here is a research article detailing some of the beneficial qualities of L. rhamnosus in the context of histamine:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042653/

  31. Chris,
    Your article is very informative but I have to share my story. In June of this year, I suddenly developed what seemed to be a sulphite allergy. I woke up at 3 am to find my tongue had swollen to fill my mouth. I knew I had problems with sulfur drugs, and the evening before I’d had a glass of wine (a brand that had contains sulfites on the label). Pretty easy, I thought – after all, we already lived a whole foods diet, avoiding sulfites didn’t seem like such a big deal. But two weeks later, I began to have allergic reactions to literally everything I ate and drank – mouth burning constantly, extreme drops in blood pressure, blurred vision – you name it – I thought I was going crazy. Two more runs to the ER, and everyone in traditional medicine trying to get me to have tradition allergy testing done and telling me the best I could hope for was to “manage my symptoms.” I didn’t agree and thought that there had to be an underlying problem with a system in my body. So, instead, I went to a nutritionist for MRT-LEAP testing -helpful but I couldn’t advance through the protocol. It wasn’t helping me with what she and I thought was HIT. I then had MTHFR testing and discovered I have two hetero- mutations but no high levels of homocysteine. She also had me tested for the gene for celiac disease -negative. Thankfully she then sent me to a naturopath. He had me tested for liver function, SIBO, thyroid, hormone, and adrenal function. No SIBO, no NASH, but guess what? I have absorption problems with my gut causing my liver and galbladder to not release what they should and the saliva test for adrenal function showed my glands were barely producing any cortisol (at noon, I only had a reading of 1.9). I never knew that cortisol helps regulate histamine response.

    Flash forward 6 weeks and I’ve been taking everything the naturopath recommended and the good news is I’ve been able to expand my diet from one that was mainly organic white rice and gluten free oatmeal to meals with hormone free chicken, fresh vegetables, and fruit (fruit always caused the worst of the blood pressure drops). I’m feeling much better and feel like there is light at the end of the tunnel.

    Your site and newsletters helped a lot when I thought I had HIT, but I’d like to recommend that you have clients run tests on their adrenal function. Get them away from the traditional medical establishment – the naturopath told my husband, “they’ll wait until your wife has a disease to help her – I’m not waiting for that to happen.”

    Tell your clients to manage their stress better – that’s the task facing me so my adrenal stress doesn’t return.

    Thanks!
    Debbie, aka QuimbysMom

    • Hi Debbie x im glad you are making progress. Malabsorbtion is seen in mast cell diseases. These conditions. also intetact highly with cortisol. So woth your anaphylsxis – swollen tpunge etc and malabsorbtion i suggest testing for mast cell activation syndrome . mastocytosis and mimicing conditions . I say this as these conditions need controlling to prevent damage to organs . My perspective is way past ige allergy alone . Ige is only one of over 100ways mast cells are activatrd and histamine one of 200chemicals released either imnediately on activation or over the following hrs .

    • Hi Debbie,
      In many ways your story sounds very much like mine. Many times I read how a person shouldn’t take away foods from their diet when they start having troubles. Like you my body began to reject foods, healthy, important foods. I was down to trying white rice because I didn’t eat it before. Dairy which I also didn’t consume before. It was crazy! Slowly I have be able to introduce some nourishing foods as well and feel much better.

      I definitely agree that stress can be a huge trigger with these problems.

      Best of luck to you.

    • Hi Debbie–thanks for sharing your story. Could you please share the specific recommendations your naturopath made for your malabsorption issues and also your adrenal fatigue issues? I am dealing with both issues and would very much appreciate your feedback–thank you!
      Michael

  32. Hi Chris,

    Thanks, as always, for the fascinating information.

    –In your clinical experience, do you ever have patients who find that addressing “histamine intolerance” is helpful even when they _don’t_ suffer from the standard histamine issues (such as sneezing, “allergies,” etc.)?j In this case, I’m referring to the possibility that mood disorders or other non-allergy-type symptoms can be caused in part by histamine problems – I’ve often discounted histamine as being a problem if a person doesn’t have sinus etc. issues.

    –Can a serum histamine test give any useful information in the absence of a DAO test?

    Regards,
    Sarabeth

  33. With so much attention on methylation in the last few years, some people are going overboard with taking methyl donors. There seems to be a sweet spot for each person with regard to methyl donors and amounts, especially folate and TMG supplements. (One can read various in the literature and message boards about TMG and histamine, but from my experience it’s a *major* histamine aggravator.) Over-methylating raises histamine, and can do so for much longer than we might suppose, even weeks or several months after quitting the offending substances. The problem can be worse if timing coincides with an environmental allergy such as pollen, or a food allergy, that the person has but might not even be aware of or wasn’t bothered by before.

    Immune boosting herbs, elixir tonics, and supplements can be another contributor. In a person with high histamine, their immune system is already overactive, so pushing it further can be a mistake. Especially in people with high Ayurvedic pitta constitutions or conditions.

    Low thyroid such as Hashi-hypoT, especially if undiagnosed, untreated, mistreated, or undertreated, can foster allergic reactions, especially to molds.

    Chris mentioned cortisol. Low cortisol is often found in young slender adults lacking physical endurance and chronically fatigued, and in persons burnt out from overtraining, excessive running or other excessive cardio. Normal cortisol would help keep allergic inflammation in check.

    On the other hand, a prior course of cortisone steroid meds such as after eye surgery (e.g. a combo antibiotic-steroid med) can leave the system off-balance and tentative for months in terms of how to react to the environment, and can be a setup for histamine reactions.

    I’ve not noticed any major histamine dampening effects of quercetin, bromelain, or pine bark. Nor histamine aggravating effects from L. casei, L. delbrueckii, or L. bulgaricus. However everyone is different.

  34. The whole histamine puzzle is insane! I believe things like candida, yeast, mold toxicity>mold sensitivity/allergy are very overlooked factors. When it comes to mold i believe indoor environmental factors and outdoor environmental, climate, and geographical factors are hugely implicated and overlooked. ex: living in a coastal area vs a dry agricultural based area, rural area vs city, altitude, latitude, etc.

  35. Thank you for posting this, Chris! I have horrible headaches that last for four days every month starting on the 3rd day of my period. I have found avoiding these high histamine foods helps, but do you have any other suggestions for avoiding the headaches in the first place?

    • yes x quericitin or other mast cell stabilisers are proven to prevent stress /hormone (research proven ) mast cell activation . They reduce activation and so release of the chemicals which cause migraines . Histamine . serotonin . prostoglandins . tnfalpha are amoungst these .

  36. Chris, thanks for the great info. I was wondering if prostate issues have any relation to histamine. In doing research on both issues, it strikes me that many of the supplements recommended as natural antihistamines (e.g., quercetin, stinging nettles, pine bark) are also recommended for prostate issues. Any thoughts?

  37. Also, how much time before adding something back in? Let’s say the symptoms have subsided w/ dietary intervention, and are under control. How long before you’d add a food in? What should be a first food? Sauerkraut, because it should have L. plantarum?

  38. Serum Tryptase is one marker for Mast Cell Activation Syndrome. Most of us who have MCAS, as I do, have low Tryptase. Individuals with Systemic Mastocytosis are the ones who usually have high Tryptase. We have the same symptoms and problems as SM patients but our mast cells do not proliferate or very little. There are several other tests that can be run like Chromogranin A, Heparin, leukotrienes, prostaglandin D2 and N-methylhistamine in urine.
    Most MCAS patients have problems with many food, even those that are considered low histamine. I’m guessing that’s because the mast cell releases many other mediators other than histamine.
    The food is the least of it, as you described the different systemic problems that can be an issue. Thank you for mentioning that there can be other reasons for having this disease. We are NOT all at the bottom of the health ladder when the disease emerges. It is thought that we have some of these problems since childhood.
    Unfortunately another thing that we react to are supplements and medications. I tried Prescript Assist in a very small dose, to work my way up, and had a bad reaction. That’s how it goes with us. A lot of research and testing on ourselves to figure what helps or hurts us. Very few professionals are able to help us.

    • Hi Yolanda x there are good drs out there and i will happily direct you . The issue with supplements in those with mcas is often non active ingedients . This is the same for -mast cell safe – drugs . See my site for aviod meds and known exipetents which cause issues . For sm a tryptase needs taking on a normal day and in the first hr of a reaction -if its over 20 then further testing for sm will be given . If not then a set formula comparing baseline and reaction tryptase is used . Other issues should be considered with normal tryptase x

  39. Hey Chris, Thanks for this podcast. I did get my DAO measured and my Naturopath said it was fine so I would not have histamine intolerance. However I am doing Autoimmune paleo for a year now and my gut is still so leaky I have yellow stool every day, I need to go to the toilet every time I eat something and I am anything but feeling good. I have severe stomach pain constantly only when I do not need eat anything. Does it mean there has to be something with histamine. I am unsure to what I am reacting as I am just generally very inflamed and simply always in pain for over a decade now. Maybe I should mention that I have Candida and Hashimoto.

    • You might have a problem with a gallbladder issue (whether it has been removed or not). Try taking an ox bile salt tablet before eating. Also, try smoothies (a combo of fruit and vegetable in the blender) for breakfast/lunch to help settle your digestive system.

  40. I’d like anyone that thinks histamine intolerance isn’t real to live a week of my life, it is hell…my dr couldn’t find the test to check diamine oxidase levels, can you tell me what the test is? Thanks!

  41. I am at my whit’s end. …itching. Intense itching occurs in my skin when I go out for a walk and my skin isn’t completely warmed up. …I took a walk yesterday. Bundled up on the top portion of my body- boots and just one layer of pants in the bottom half of my body. At some point… The itching started. The tops and inner thighs. So intense, I had to itch, then it spread… The backs of my thighs… My rear end. It is so awful. …. I know there is a circulation issue here… And I generally have cold hands, feet, nose. History: I used to go on 10k trail runs in college. At some point in college after that, I noticed the itching. And it has altered my life ever since. Unless I bundle up in multiple layers- I mean many many layers, I cannot go out on a brisk day and take a walk or run without itching. I am MTHFR heterozygous. — I did the whole30 program, and drank a small amount of kombucha. I brew it. … Still itched. I gotta get to the bottom of this. It has altered my life too much, and NO MORE. help.

    • Hey Lindsey–sorry to hear about your cold sensitivity etc. I too have a skin issue that is sort of the opposite–I have reactions to very hot water (can’t take baths or hot tubs)–esp in Winter when my skin is very dry. It ended up being an internal fungal/bacteria imbalance–sort of related to leaky gut. So after seeing 6 “specialists”–it was my ND who diagnosed and treated it. I wonder if yours is related? The 30 day diet is a huge step in right direction–but if I were you, I would try 3-6 months of the low histamine diet that Chris describes. Esp avoiding anything fermented (including kumbucha). The 30 day diet thing is great for an initial cleanse, but it won’t treat the histamine issue, if that is what you have. Here is what i know for sure–the low histamine diet CANNOT do any further harm–and it may help. Once you have done the diet for at least 3 months (seems like a long time–and the first two weeks are really hard–but it goes super fast–have to have some resolve!)–then any bad bacteria imbalance will be weak and starved–then work with an ND to crowd it out with the good bacteria that Chris mentions above for about a month, and then finally, kill it with a natural funguscide (there are a few out there–some combo that contains oregano oil, black walnut, quassia, wormwood etc). Hope this helps! We need to take control of our bodies!! 🙂

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