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Is it Possible to Get Off Thyroid Medication?


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Revolution Health Radio podcast, Chris Kresser

As is often the case, when we look at a question like this, it becomes a lot more complex and it may seem initially, on the surface. Let’s tackle issues number two through four first, because they’re actually going to inform the answer to the first question, which is, is it possible to get off thyroid medication? In terms of diagnosing Hashimoto’s, it’s actually not quite as straightforward as just doing an antibody test and seeing what the results are. I wish it were.  It would make my life a lot easier, for sure. But the first-line test you do, typically what I do, is for antibodies. By antibodies, I mean thyroperoxidase and thyroglobulin antibodies, these are the two antibodies that tend to be elevated in Hashimoto’s. Thyroperoxidase is elevated a lot more often than thyroglobulin. It’s more sensitive to Hashimoto’s. It’s not more specific. So you’ll tend to see it elevated more frequently.

In this episode, we cover:

3:15  What Chris ate for breakfast
6:36  Are antibodies reliable in diagnosing Hashimoto’s?
14:50  Can you reverse autoimmunity?
19:13  3 issues that cause T4 to T3 conversion problems
30:46  Is it possible to get off thyroid medication?

Links We Discuss

Steve Wright: Hey, everyone. Welcome to another episode of the Revolution Health Radio show. This show is brought to you by ChrisKresser.com. I’m your host, Steve Wright from SCDlifestyle.com. With me is integrative medical practitioner, New York Times bestseller, and healthy skeptic, Chris Kresser. How are you doing, man?

Chris Kresser:  I’m great, Steve. How are you?

Steve Wright: I’m doing good. I’m reintegrating back into life.

Chris Kresser: I want you to tell everyone a little bit about what you’ve been up to these last couple weeks.

Steve Wright: Okay. Well, it depends on how the sound comes out. I apologize, everyone. They’re doing massive construction outside of my new apartment. I’m in the kitchen right now, trying to find the best acoustics. So I went on a 10-day Vipassana meditation retreat. That form of meditation retreat means absolutely no self-expressionno talking, no writing, no exercising. You just meditate for approximately 12 hours a day. The only people you can talk to are the teachers or the management staff. That wrapped up about five days ago. It was transformational. It was one of the hardest things I’ve ever done, no doubt, but it was so worth it and so amazing. I don’t think words can really express what I’ve gotten from it.

Chris Kresser: I know what you mean. It’s such a powerful, like you said, transformational experience. It’s a big commitment to make. But as you shared with us, I know from my own experience that there’s really nothing else like it. There’s no other. It’s such a precious gift to give to yourself. I’m so glad that you did that.

Steve Wright: Thank you. I knew I didn’t know myself, but just getting to spend some time with yourself I think was so amazing. I know that there are lots of different forms of meditation. We’ve talked about it on the show a lot. I can’t thank you enough Chris for pushing me in this direction towards meditation. It’s something I probably wouldn’t have done, had we not been friends for the last couple of years. So thank you for contributing to that.

Chris Kresser: Oh, my pleasure. You’re the one that made the commitment and did it. It’s really amazing to see what comes out when you’re just sitting there on a cushion, you have no distractions, and none of our typical things that we do to distract ourselves from what we’re feeling or thinking. It’s quite a valuable experience, isn’t it? Maybe we’ll put up a link to the Vipassana website that has a list of all the centers, in case people want to give it a shot.

Steve Wright: Awesome. Well, I think the Vipassana Association would love us sending some traffic their way. Enough about meditation, Chris. What did you have for breakfast?

What Chris Ate for Breakfast

Chris Kresser:  oday, I had cold-brewed coffee with some cream. It was an intermittent fast day. I just didn’t feel particularly hungry when I woke up. I had kind of a late dinner. I knew I was going to be recording. So that was it.

Steve Wright: Awesome.

Chris Kresser: So we have a great question today. I think it’s going to be relevant for a lot of people. We’ll give it a second to play, and then we’ll answer it for the rest of the show.

Raven: Hi Chris, this is Raven. Love your show. I wanted to know if you think it’s possible to get off thyroid medication? I do not have Hashimoto’s, I’ve always tested very, very low in antibodies, but have had a conversion problem for at least the past 10 years. Originally, when I was put on medication, my T4 levels were good, but my T3 was very low. Now that I’ve been on medication—I’m currently using Nature Thoid and some Cytomel—and I’m trying to lower the dose. My TSH does not kick back in, so it stays at a very, very low level (.07) even when my T4 drops way below the normal. Is there any way to gradually get off medication or should I just resign to my fate? I have felt some improvement, some ability to use less thyroid medication as I’ve been working to heal my gut, which of course, is not very surprising.  Still, I’d love some words of wisdom and insight. Thank you very much.

Chris Kresser: Thanks for your question, Raven. There are actually several different issues to address here in this question, probably at least four. Hopefully, we can get through those in this episode. If not, we’ll circle back and finish it off another time.

Steve Wright: I’ve been doing a deep dive into this, Chris. So I’m ready, man. I’m ready to throw some curveballs your way.

Chris Kresser: Great. The first question was her main one, which is, is it possible to get off thyroid medication? Another question or issue to talk about is, are antibodies reliable in diagnosing Hashimoto’s in the first place? If they’re not, what is? A third issue would be, what causes the problems that we see with conversion of T4 to T3? So what causes T4 to T3 conversion problems in the first place? The secondary question there would be, is medication the best way to treat those problems or causes? Number four would be, what does a TSH of essentially zero, 0.07, and low T4 indicate when you’re taking thyroid medication? As is often the case, when we look at a question like this, it becomes a lot more complex and it may seem initially, on the surface.

Are Antibodies Reliable in Diagnosing Hashimoto’s?

Let’s tackle issues number two through four first, because they’re actually going to inform the answer to the first question, which is, is it possible to get off thyroid medication? In terms of diagnosing Hashimoto’s, it’s actually not quite as straightforward as just doing an antibody test and seeing what the results are. I wish it were. It would make my life a lot easier, for sure. But the first-line test you do, typically what I do, is for antibodies. By antibodies, I mean thyroperoxidase and thyroglobulin antibodies, these are the two antibodies that tend to be elevated in Hashimoto’s. Thyroperoxidase is elevated a lot more often than thyroglobulin. It’s more sensitive to Hashimoto’s. It’s not more specific. So you’ll tend to see it elevated more frequently.

Steve Wright: And elevated means anything above zero or lab range elevated?

Chris Kresser: Yeah, I do use the lab range. I know some practitioners will say anything above zero is abnormal, but I don’t actually think that’s true. When you look at any kind of antibody test—even Cyrex Labs for their Array #5 multiple antibody screen or any of their gluten intolerance panels—you’ll see that a small amount of antibody production is actually not pathological or abnormal. I don’t know what the scientific basis is for claiming that thyroid antibodies being anywhere above zero is abnormal or indicative of pathology, because I’ve never seen any research to back that up. So I use the lab range. If it’s getting close to the top of the lab range, I will definitely be paying attention, because the cutoffs are always somewhat arbitrary. You know, they’re based on research and prospective studies, and I’ve seen some prospective studies that suggest to me that the lab range should be, perhaps, a little bit lower than it is. Like with thyroperoxidase, usually 34 is the upper end of the limit or somewhere around there. I’ve seen studies suggesting that if you have TPO antibodies above 30, you’re much more likely to develop hypothyroidism in the future. So it’s possible that the lab range should be a little bit lower, but I don’t think it should be zero. The problem with thyroid antibodies is, like almost any lab test that you can mention, they’re not 100% reliable as a way of diagnosing Hashimoto’s. For example, in a study of 100 South Asian Indian people that had Hashimoto’s confirmed by histological analysis—meaning actually looking at the tissue and seeing for sure that they have Hashimoto’s—about 89% had TPO antibodies and 65% had thyroglobulin antibodies. That means that 11% of people with Hashimoto’s would have been missed if you were only looking at TPO antibodies, and a full 35% of patients with Hashimoto’s would have been missed if you were only looking at thyroglobulin antibodies. There are other studies that have actually even shown lower numbers. It’s more like 75% to 80% have TPO antibodies, and as low as 40% or 45% have thyroglobulin antibodies. So what we can say from these numbers is that anywhere between 11% and maybe 30% of patients, if you run TPO and thyroglobulin antibodies that have negative results on an antibody test, may still have Hashimoto’s, even if you run that antibody test multiple times. So that’s really important for clinicians to understand, because I’ve seen a lot of patients who’ve been to the doctor a few times before they came to see me. They said, “No, I don’t have Hashimoto’s. I had an antibody test, and it was negative.” Well, you can’t really conclusively rule it out just from an antibody test or two.

Steve Wright: Did I hear you correctly there? With these people, where you can do the antibody test like 10 times or 100 times, and they’re never going to show positive?

Chris Kresser: I don’t know about 100, possibly 10. I think it’s a lot less likely if you do multiple tests, which is why I always recommend that people do two to three tests over time at least, to see if we can catch it. And I have seen that with patients, where they’ve come and they’ve had one or two negative tests. I test them a third or fourth time, and we catch the antibodies elevated on the third or fourth time. But even then, it’s not necessarily indicative that hypothyroidism is present or will ever be present. So that’s another important thing to understand, that Hashimoto’s itself doesn’t necessarily mean that you have an under-functioning thyroid gland. It means that your immune system is tagging the thyroid gland for destruction. It doesn’t even necessarily mean that destruction of the tissue is occurring actively. And those are all not necessarily connected. They’re likely to be connected, but they’re not necessarily connected. There are a certain percentage of patients, and I think it’s actually over 50%, who produce thyroid antibodies that don’t go on to develop frank hypothyroidism. Of course, people with thyroid antibodies have a much higher likelihood of developing hypothyroidism in the future. In fact, it’s over sevenfold; I think seven- and ninefold greater risk than people without antibodies. But it doesn’t mean that if you have antibodies, that you a) for sure, right now, have hypothyroidism, or b) will ever develop hypothyroidism. That’s important to understand as well.

Another test that your doctor can run—typically an endocrinologist will do this test—is a thyroid ultrasound. So they’ll run an ultrasound on your thyroid gland and your neck area. What they’re looking for typically are nodules, little bumps on the thyroid gland, especially if you have a multinodular goiter, like a little mild swelling with a lot of little nodules there. That’s indicative typically of an autoimmune pattern, Hashimoto’s, or if you have hyperthyroid type of symptoms, Graves’ disease. So if you really want to get the best view of whether you have Hashimoto’s, it’s good to combine antibody testing with a thyroid ultrasound. Of course, you could do a biopsy, which would be the most accurate way of detecting Hashimoto’s, but that’s very invasive.  ou know, sticking a needle in your neck and aspirating tissue there is not very appealing and is potentially dangerous. Given the fact that Hashimoto’s is not fatal or not necessarily even debilitating—although it can be—it’s generally judged to not be worth the risk in the invasiveness of that procedure. So it’s the thyroid ultrasound and the antibody testing. In my practice, if there’s someone that’s had a negative ultrasound and they’ve had a few negative antibody tests, but I really still suspect that autoimmunity is a cause, maybe they have another autoimmune disease or maybe they just have the signs and symptoms of autoimmunity, then I will do a therapeutic trial of an immune-balancing regulating treatment and see how they respond. If they respond really well to that, then that’s really all the evidence I need to help do an immune-balancing regimen from a functional medicine perspective. So that’s the baseline here to understand in terms of Hashimoto’s, because there’s a lot of misunderstanding I think out there in both the conventional side and the alternative side about how to diagnose it and what it means if you actually have it.

Can You Reverse Autoimmunity?

Steve Wright: Chris, the listener is asking about coming off medications. But we’re talking about Hashimoto’s, and coming up and down in lab ranges that might not even be existent. We’re talking about treatments that sometimes we just use. The question I’m wondering is, “Is there a point where autoimmunity just stops?” Or are we always a little bit autoimmune? I guess what I’m trying to ask is, should people be thinking or should the goal be, to cure or reverse autoimmunity? Or are we approaching a limit of infinity of what is actually possible inside the body?

Chris Kresser: Well, I can tell you the conventional view, and then we can speculate and look at some alternative views. The conventional view is that once antibody production starts to a tissue, it doesn’t stop. That’s a good thing mostly. If you get exposed to a virus or a pathogen—any kind of pathogen that we can produce antibodies to—that’s the way the immune system is designed to work. If you get exposed then to that pathogen 20 or 30 years later, you have these memory cells that remember and can start producing antibodies to that pathogen again, even 30, 40 years later. That’s the brilliance of our immune system. So you only really have to be exposed once, and then you’re protected from that for a lifetime. That’s when things are functioning well. But that really clever system can backfire on us when what we’re producing antibodies to is tissue in our body, right? Because once that antibody production starts, the immune system is designed to remember, so that it will always continue to do that. So that’s the conventional view. Then in that way of looking at things, autoimmune disease is not curable. It’s only manageable. What you can do is reduce the environmental triggers that provoke and exacerbate the inflammatory response that destroys the tissue that we’re producing antibodies to. That’s why we talk so much about things like the autoimmune Paleo protocol and glutathione and things that promote regulatory T cell function. Others have speculated more recently that things like intestinal permeability is a precondition for the development of autoimmunity, and that it’s possible, in certain circumstances, that healing the gut, reducing that permeability, for example, would stop the process of autoimmunity and essentially cure it. I don’t really think we know enough about that yet to say whether that’s possible. What I can say is it probably depends on the definition of cure.

So let’s think about something like celiac disease. If you remove gluten from the diet and possibly other grains and dairy and cross-reactive proteins, that person could become completely symptom-free, right? So is that a cure? It depends how you define it. Generally, if that person starts eating gluten again, they’re going to get very sick. In the strict definition of a cure, that’s not really a cure, because a cure would be getting them to the point where they can eat gluten with impunity and not experience any symptoms at all. So it’s not a cure, but it’s effectively managed to the point where they don’t even have symptoms at all, by making some relatively simple changes in their life—maybe not easy, but relatively simple. That’s kind of the way I look at it, is that these conditions can often be managed to the point where the symptoms are either gone or not intrusive in one’s life. But as far as that background autoimmune reaction, I haven’t yet seen a lot of evidence—either clinically or in research—that that can completely be cured to the point where there’s no change required.

Steve Wright: Awesome. Thanks for opening that wormhole.

Chris Kresser: Sure.

Steve Wright: Let’s keep rolling here.

3 Issues That Cause T4 to T3 Conversion Problems

Chris Kresser: The third question we wanted to address was what causes T4 to T3 conversion problems. If you recall, T4 is 94% of what the thyroid gland produces in terms of thyroid hormones. Then that T4 has to get converted into T3, because T4 is not very active metabolically. T3 is the thyroid hormone that really activates the cellular receptors and does everything the thyroid hormone is supposed to do. So the thyroid gland produces most of the T4, and then elsewhere—not in the thyroid gland, but elsewhere around the body—that T4 gets converted into T3, which is the active form.

What Raven is asking about, what we often see is people who have either normal or low normal T4, and then they have low T3. What that indicates actually is that the thyroid gland may be functioning okay, but the conversion of T4 to T3 that’s happening all around the body is not working well. That’s a really important thing to understand. T4 to T3 conversion problems are not thyroid problems. They’re not problems with the thyroid gland. They’re problems that are caused elsewhere in the body that affect the thyroid system. They affect the cell’s ability to receive T3 thyroid hormone. They’ll manifest in hypothyroid symptoms, but they’re not actually a problem with the thyroid gland. It’s crucial to understand that, because it completely informs how we address T4 to T3 conversion problems. For example, giving the patient a whole bunch more T4 medication is probably not a great idea in that situation, because the T4 is not being converted into T3. But that’s the standard treatment for a lot of thyroid problems, is just to give Synthroid or levothyroxine, which is a T4-based medication. So what’s going wrong in this situation? It’s usually three primary causes: inflammation, poor gut health, and very low-carb diets, if the person is in that world.  Inflammation and inflammatory cytokines can really mess with T4 to T3 conversion in several different ways. Let me back up. Inflammation can suppress T4 to T3 conversion. It just inhibits that process, but it also messes with thyroid function in other ways.  It reduces the pituitary output of TSH, and it also reduces the cellular sensitivity to thyroid hormones.  So even if you have enough T3 floating around in your system, your cells can’t receive it. And it doesn’t activate the cellular receptors, so you end up with symptoms of hypothyroidism, even if your labs are normal. That’s inflammation. Poor gut health. 20% of the conversion of T4 to T3 actually happens in the gut. If you have poor gut health, disrupted gut microbiome, SIBO, parasites, leaky gut, then it’s entirely possible that that T4 to T3 conversion that’s supposed to happen in the gut is not happening or not happening well, at least. Of course, gut problems typically lead to inflammation, so you get a little bit of a double whammy there when you have gut issues.

Steve Wright: Chris, so with 20%, obviously, it’s probably not 0% to 20%. Like, if you have a banged up gut, it’s zero then. We’re talking about a range, so it’s some fraction of that. Between the body and inflammation, we’ve lost 10%—is that enough that we’re going to be feeling that on a daily basis?

Chris Kresser: I think it will depend on the person. The more real-life scenario is probably, let’s say you lose 10% of the conversion in the gut. But you have inflammation, because your gut is screwed up. So that inflammation is also reducing T4 to T3 conversion outside of the gut. So that’s maybe another 10%, 20%. I mean, these numbers are just made up.  I have no idea. I don’t think there’s ever been a study that shows exactly that. Then let’s assume that your cells are less sensitive to the effects of thyroid hormone that you do have because of this inflammation. Even though you maybe only have a 20% reduction of your T4 to T3 conversion, you’re not as sensitive to the T3 that you do have. So you get all of these factors that combine to reduce the effectiveness of your overall thyroid system. That’s probably more how it happens in the real-world scenario. Then maybe you’re on a very low-carb diet, because you’re trying to lose weight or you’ve just been told that that’s a good kind of default approach. The problem with that is insulin is required to convert T4 to T3. We hear a lot of bad things about insulin, and certainly insulin resistance is not good. But insulin is a vital hormone. It plays a lot of important roles. One of them is this conversion of T4 to T3. And if you’re on a really low-carb diet—like a ketogenic diet—over a long period of time, you’re bound to have very low insulin levels. This is in some people, not everyone. I’ve talked about this a lot. I’ve talked about it on Jimmy Moore’s show. We’ve had a lot of discussion about this. I want to be clear that this doesn’t happen to everybody. But it’s more likely that someone who’s on a ketogenic or very low-carb diet will have low levels of T3. So those are the three main issues—inflammation, poor gut health, and very low-carb diets—that can cause T4 to T3 conversion problems. What that means, from a clinical perspective, is that just giving more T4 medication is not the answer. And even giving T3 medication, although it can help, is not really the answer from a functional medicine perspective. That’s because that’s kind of putting a band-aid on a problem. And sometimes band-aids are necessary, they help protect the wound and help it to heal. But you really want to address the underlying problem with functional medicine to get the best long-term result. If you need to use a band-aid for a period of time while you’re doing that, that’s fine. There’s nothing wrong with that. I do that in my practice. But not at the expense of addressing the underlying issue.

Steve Wright: Yeah. I think it’s always important to be thinking short-term, how can I have the best quality of life possible? And then long-term, how can we get this whole thing handled?

Chris Kresser: Exactly. Another analogy we often use in functional medicine is a tree. In order for a tree to have healthy branches and leaves, you have to take care of the roots. But sometimes you need to do a little bit of pruning on the branches, in order for the tree to be healthy too. So it’s not just that we are, at the exclusion of all else, focusing on the root cause, but it’s that we always want to do that at the very minimum. Then on top of that, we may also need to address the symptoms specifically, just for someone to feel better and function in their lives.

Okay. The last piece we need to talk about is what’s the significance of a TSH of zero—or 0.07 I think it was for Raven—and low T4 when you’re taking thyroid medication, particularly thyroid medication that has T3 in it. Typically, with a TSH of zero, it either means you have hyperthyroidism, if you’re not taking thyroid medication, but if you’re taking thyroid medication, it means your dose is too high. That’s because if you recall how the thyroid system works, the pituitary is a gland in the brain. It’s like the control tower that’s constantly monitoring the levels of all hormones in the body, and in this case thyroid hormone. When thyroid hormone levels are high or higher than what the pituitary thinks they should be, it will reduce the output of thyroid-stimulating hormone (TSH). That’s the signal that it sends to the thyroid gland to tell it how much thyroid hormone to produce. So if thyroid hormone levels are high, TSH will drop, because the pituitary is basically saying to the thyroid, “Hey, we’ve got more than enough as it is, s don’t make any more.” On the other hand, if thyroid hormone levels are low, then you’ll see TSH go up, because the pituitary, at that point, is shouting at the thyroid gland, “Hey, kick things up a little bit. We’ve got low levels of hormone.” So when you see a level of zero, that means the pituitary is like slamming on the brakes and saying, “No more thyroid hormones. This is too much.” That’s a sign that your thyroid medication is too high typically. So you’ll want to speak with your doctor about modulating the dose of the medication, so that your TSH range is back in that normal range of 0.5 to 2.5. That’s the functional optimal range for TSH.

In terms of low T4, that’s also typically a reflection that you’re taking thyroid hormone, particularly T3, because if you think about it again, the way that the body protects itself from too much hormone is it would tell the thyroid to produce less thyroid hormone. Then the thyroid itself would produce less thyroid hormone, which is T4. So seeing this pattern is very typical when someone is on thyroid medication. Now I do want to say that if TSH is normal or at the low end of the range—like 0.5 or something like that—and T4 or free T4 is slightly low—maybe 0.8 for free T4 or maybe 5 for total T4—that’s not necessarily a problem. That’s indicative that you’re taking supplemental T4, T3 combination or just T3 alone, and it’s not a problem. What determines whether it’s a problem is the TSH level. So if the TSH is at zero and T4 is low, I would say that’s a clear indicator that the medication dose is too high. If the TSH is normal and the T4 is slightly low, I would say that’s probably not an issue. Of course, we have to say that before you make any changes to your medication, make sure to speak to your doctor. Don’t take this as medical advice. I’m just sharing with you what the research says about these numbers and what this means.

Steve Wright: What happens if TSH is above 2.5, like 5 or something?

Chris Kresser: If TSH is above 2.5, it means your dose is too low or you’re not addressing other fundamental problems, like the gut issue, the inflammation, and some of the other things that we talked about.  That’s probably a topic for a separate show. But the lab range for TSH, as I mentioned, is too broad. It’s usually 0.5 to 4.5. But more recent studies have shown that the normal range for a healthy, functioning thyroid, the TSH range is 0.5 to maybe 2.2, at most 2.5, but definitely not 4.5.

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Is It Possible to Get off Thyroid Medication?

Okay, let’s wrap this up. I know we’re probably going a little longer than normal today. Let’s circle back now to Raven’s main question, and a lot of people’s main question. I hear this all the time. Is it possible to get off thyroid medication? The answer, after everything that we just went through, is it depends. It’s always the answer, and it’s true. It depends, of course—I hope you can see this now—on what’s causing the problem. In Raven’s case, if she truly doesn’t have Hashimoto’s, it’s possible that fixing the gut and reducing inflammation, if that’s what’s causing the low T4 to T3 conversion, would be enough to resolve the problem, and she wouldn’t need to continue to take thyroid medication. Or maybe in another situation, if we found out that Raven was iodine deficient and that was the real cause, or selenium or zinc deficient—I’m going to add this back to T4 to T3 conversion problems. Selenium deficiency and zinc deficiency can also cause problems with T4 to T3 conversion. If we find that she’s deficient in selenium and zinc, we restore those nutrients, the T4 to T3 conversion improves, no more need for thyroid medication.

Steve Wright: Since you just opened the wormhole again, do you want to throw neurotransmitters in there too?

Chris Kresser: That will just take us too far down the rabbit hole, so we’ll come back to that.

Steve Wright: Okay.

Chris Kresser: So if the cause of the thyroid problem in the first place can be addressed, then yes, you can get off the thyroid medication. But what if Raven does have Hashimoto’s, and what if she had it for 20 years before she developed hypothyroidism, which is entirely possible and often common? And what if, over that period of time, the immune attack against the thyroid gradually destroyed the thyroid tissue, which is where thyroid hormone gets produced? In that case, it’s probably not possible and not even desirable to get off of thyroid medication, because thyroid hormone is so essential to every cell in the body that any potential downside of taking thyroid hormone replacement—either like a pharmaceutical approach, synthetic, like Synthroid or levothyroxine and Cytomel, or bio-identical porcine thyroid source medication like Armour or Nature-Throid or desiccated pig thyroid that you can buy over the counter—that would all be advisable over the long term in a person like that. That’s because they need the thyroid hormone to function well, and their thyroid gland is compromised. And as far as we know, that tissue doesn’t grow back. So in that situation, in that person, it wouldn’t be possible for them to get off thyroid medication. It wouldn’t even be a goal that they should be thinking about. So it really depends on the situation, as I hope you can see from today’s show. Raven, I hope that answers your question. I hope everybody else got something out of that as well. It was a lot of information in a short time, but hopefully, that helps.

Steve Wright: I think the wrap up there was great, Chris. We didn’t start the show like that because it would have led to a five-hour show. But the thyroid is part of the HPA TG axis. The thyroid is right in the middle of that large acronym of basically all of your hormone structures. So if you’re someone who’s bent on getting off your thyroid medication or stay in this, you’ve got to think about that whole chain, because they all interact together. We’ve only touched upon that topic today. It sounds like Raven has a lot to work with.

Chris Kresser: I hope so. Thanks again, everyone, for listening. Steve, good to have you back. We’ll see you next week.

Steve Wright: Thanks, Chris. For listeners looking for more information in-between episodes, make sure you go to Facebook.com/ChrisKresserLAc and Twitter.com/ChrisKresser.

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  1. Interesting show. Thank You! I’ve been on Dessicated Porcine Gland (DPG) for 14 years. I was diagnosed with Hashimotos in 2004 but then on other tests over the years it goes back and forth between antibodies. My TSH went down to 0 last year and they found a small nodule and did a biopsy to see if it was cancerous. No cancer. My doctor lowed my dosage and my TSH is now at up to 0.24 even though 0.50 is normal. He has decided I’m okay at this level, which I feel great and seem to have no symptoms of Graves or HyperT. Anyway, I beginning a protocol of Carnivora, Wobenzyme N along with Probiotics to address inflamation in the gut and in my left knee where I underwent 2 orthoscopic surgeries in the past 2 years (Meniscus Tears (medial in 2015 lateral in 2016). Here’s the question… If the inflamation and gut issue is resolved will the conversion from T4 to T3 improve? Which will mean I can decrease the dosage of DPG? Also do you know where I can find information on side effects of Dessicated Porcine Gland? I’ve looked all over and can’t seem to find any, so perhaps their aren’t side effects? Thanks so much! lower.

  2. Interesting show. Thank You! I’ve been on Dessicated Porcine Gland (DPG) for 14 years. I was diagnosed with Hashimotos in 2004 but then on other tests over the years it goes back and forth between antibodies. My TSH went down to 0 last year and they found a small nodule and did a biopsy to see if it was cancerous. No cancer. My doctor lowed my dosage and my TSH is now at up to 0.24 even though 0.50 is normal. He has decided I’m okay at this level, which I feel great and seem to have no symptoms of Graves or HyperT. Anyway, I beginning a protocol of Carnivora, Wobenzyme N along with Probiotics to address inflamation in the gut and in my left knee where I underwent 2 orthoscopic surgeries in the past 2 years (Meniscus Tears (medial in 2015 lateral in 2016). Here’s the question… If the inflamation and gut issue is resolved will the conversion from T4 to T3 improve? Which will mean I can decrease the dosage of DPG? Also do you know where I can find information on side effects of Dessicated Porcine Gland? I’ve looked all over and can’t seem to find any, so perhaps their aren’t side effects? Thanks so much! lower.

  3. I have Hashimoto’s. I have been on 75mg of Armour for almost 3 years. Also, gluten free (modified SCD) for 5 years. Over the past 6 months my TSH has drop from 1.4 to 0.02. My T3 has always been around 2.3 and T4 .7-.8.

    My most recent test showed a T3 of 3.3 and T4 of 1.2 and TSH of 0.02 (FYI, I had not taken Armour in 26 hours prior to labs). My doctor wants to reduce my Armour, but my understanding is that Hashimoto’s is killing my thyroid and that if anything I would need to increase doses in the future. Is it possible that I am healing and a decrease in dosage is a good/necessary thing?

    • Hi, I had TSH of zero 0 and they found a nodule on the thyroid and did a biopsy which was not cancerous. They lowered my dosage of dessicated porcine gland by 1/2 grain and now the TSH is 0.24 and I still feel great! I was concerned at first thinking I may become exhausted because I do well with TSH under 1.0 Not sure if this helps…

  4. Is there something addictive in this stuff or something? Im on natural thyroid extract and when the medication is too high I feel so wired and I can’t sleep and my body is so exhausted but cant switch off. And my throat gets tight and like a lump and I cant keep my eyes open when medication is too low. Its 10 months and the levels are still not right and I cant handle waiting every 6 weeks to change my dose, my body is struggling to go on. How on earth can I get off this stuff!?!? I am trying to heal through herbal tonics. diet etc and I think its really affecting the medication levels but if I dont do it I wont get my dose down but its really stressing out my body. I tried once to stop taking it and I went into a crash I dont want to do that again. Such a vicious cycle HELP!!!

    • I had the same problem, but I saw my doctor every 2 weeks to avoid the 6 week pains. When TSH got to zero 0 they lowered the dosage in very small increments (1/4 grain) I’m taking compounded dessicated porcine gland. Also, don’t know if you have Hashimotos, but I hope you don’t as they cannot prove anything at this time regarding reversing it. One time the test said I was ‘negative’ for Hashimotos and I was amazed! Then other times I’m tested ‘positive’. My initial tests stated that I was positive with Hashimotos. Be well!

  5. My name is Maryann, and I was just recently taken off my synthroid because I was told I have both hyper thyroid and hypo throid. I have had thyroid problems since 2002. Is it safe to be taken off my meds. I really can tell the difference by not taking them?

  6. Hi,
    I would like to ask about supplementing iodine while on Armour Thyroid – my doctor said that it is not needed. Is it helpful for Hashimoto? I am trying to eat some food with selenium, especially nuts, supplement zinc but I have still lots of antibodies – Thyroid Peroxidase Ab- 255.3 this month.
    I am taking 1.5 grain for over 6 years. Previously I was on Levothyroxine 100mcg but gradually I started to feel bad. After stopping possible chlorine and fluoride sources (5 years), also going gluten free about year ago, taking Armour twice a day – 1 grain in the morning and half in the evening my blood test are better. TSH, which was always low- now is 0.65, Free T3- 4.0, Free T4-12.4 (was low since 2014). Glucose fasting is changed – according to Australian norms- 3.6 low, but it should not be an issue (I eat only fruits, veggies, meat – no processed sugar or starches). I could not find anything about Anion Gap which I have always higher 17-18. Maybe it is connected to gut issues, which I have difficulties to solve- irregular shifts, luck of breaks, proper sleep etc…

  7. I was put on nature throid 3 wks ago. I was on 100 mcg. of levothyroxine, which I felt horrible on!. I had a complete hysterectomy 18 years ago and chose not to go on HRT. Probably should have, I think that is what threw my thyroid off 18 hears ago. I have hypothyroidism and really low blood pressure. I feel better so far on the 1 grain of nature throid and my integrative practitioner has put me on 10 mg of sublingual progesterone. She also put me on licorice root to assist with my low blood pressure. My question is the Nature throid or the HRT making my low blood pressure worse and should I go off of the HRT since that has a tendency to lower blood pressure, or switch to a different thyroid med?

    • Kelly, Your journey sounds so much like mine! I am currently experiencing such low BP I have a appt at Mayo Clinic to try to figure it out. Can you please contact me? susantech [at] stormymonday [dot] net

  8. Hi Chris,
    Thanks for your great info. I’m curious what you think about someone (me) who has Extremely high antibodies but doesn’t
    have many of the classical symptoms…I do have some but in all
    the posts, no one mentioned high numbers like mine ( 1000+)
    and I’d love to hear your thoughts on this. Thanks so much!

  9. Cannot get dose of armour correct- trying for 2 years. Started at 30mg raising every few months to eventually 120mg. Now back down to 60 mg. Last labs on 75mg: TSH 0.020, Ft4 1.42, Ft3 3.0. Just started on the 60mg and will check labs in 3 months. I have never been able to tolerate most meds including hormones- regular or bio identical – so maybe I just cannot tolerate thyroid hormone? I do not have Hashi’s-maybe I should wean off med and see how I do? Thanks

    • My numbers are almost identical to yours. (though I have Hashi’s). I am reducing from 75 to 60mg of armour. Curious if you were able to maintain on 60mg?

  10. Hi Chuck, thank you for your article. I found it when I was stricken with a rash earlier this year. I am medically gluten free for the last 20 years. 19 years ago I became sluggish and my doctor started me on Synthroid. I was taking 75 MGC daily. When the rash hit me I was put on a hystamine diet. I found when I took the synthroid my itching increased and so did the rash. My doctor tried a compound pharmacy dye free and the issue continued every time I took the medication. Then I found your article! I started liquid iodine with yeast free selenium 150 mcg & 100 mcg. 2 months later increased the iodine to 300 mcg & selenium to 200 mcg. Couple months later my doctor tested my tsh levels and they we at slightly over 4.0
    Last couple days I’ve been feeling sluggish so I increased the iodine another drop to 450 mcg.
    Questions; should I spread the iodine Theraphy over twice a day? I am concerned if I take a partial dose in the evening it will keep me awake at night .
    Is 200 MGC selenium the proper recommended dose with 450 MGC of iodine ?
    Thank you!

  11. I was diagnosed with an under active thyroid/hypothyroidism 20 years ago. I’ve been taking a very low dose of synthetic thyroid hormones ever since. Though, I’ve gone prolonged periods of up to a year without taking it due to financisl reasons and I never feel any different. But as soon as I am able to go in for a check up and blood work I’m told the same thing again and put on the same dosage.

    Except once, after being on some high quality supplements for awhile my thyroid levels went up and they lowered my synthroid dosage.

    Then years later when finances once again prohibited me from taking these high quality supplements (that did contain iodine) my levels went down again and they raised my RX dosage.

    What does this mean? Do I have this Hashimotos disease? Am I really hypothyroid? Can I get off of the thyroid hormone altogether?

    I would really appreciate any help/info you could give me.


  12. Hi Chris
    I’m wondering about your thoughts for Hashi’s patients who don’t seem to tolerate anything with T3 in it? I have tried levothyroxine, Armour, NP, compounded, Westroid, and finally realized that the least reactive I get is to the levo (although please tell patients many forms of levo have gluten in them!)

    My free t3 is low, and I still have hypo symptoms so I’d like to tolerate T3. I’m on adrenal supplements as well as I thought that was the problem, but still I get swelling and other issues on T3 when I try again.


  13. Hi Chris, would you please clarify something? In this episode, you say the functional range for TSH is 0.5 to 2.5, but in your article, 5 Thyroid Patterns That Won’t Show Up On Standard Lab Tests, you say the functional range is 1.8 to 3.0. I’m trying to do some detective work for my wife — her TSH is 1.7 and she has low T4/T3, which would seem to match the pattern of a pituitary issue, but if her TSH is actually in the functional range, maybe I’m going down the wrong path? (She’s not on any medication). Many thanks!

    • It depends on the lab. They are not universally accepted “proper” numbers for these things. Each lab has its own “golden standards”.

  14. Chris & Steve,

    I was so happy to hear you talking about Vipassana meditation. I love those retreats! For me too the most profound experience. I have been going every year for ten years.

    I sent your article to the centre in the UK so that they could see your comments.

    Actually this brings me to a topic I seem to discuss a lot with friends and clients; vegetarianism.

    As a former vegetarian (and vegan) I am reassured to hear somebody at the forefront of the paleo movement also promoting Vipassana. The teacher at my centre pointed out to me when I was still processing all of this that the Buddha wasn’t a vegetarian and ate what was in his begging bowl. I personally feel that I managed to free myself from vegetarianism but I loved what I heard you saying on the Detox summit about the paleo diet being a predominantly plant based diet that includes animal products.

    I wrote an article recently on ‘how does a vegan do the paleo diet?’ for a vegan company

    The unanswered question I am left with though, and still need to integrate, is the killing of animals. Something inside me now says that it is a natural part of nature and that we are more removed from nature to not eat animals, but this question did come up for me to think about again when I last went on retreat.

    I tend to tell clients and friends about the book ‘beyond broccoli’ as well as the work on desertification by Alan Savoury, but any other resources or knowledge that you have to share would be amazing!

    Keep up the good work. Hope to meet you both someday. Katie Clare

    • It’s a hard thing to deal with, the killing of animals for food, for any empathetic person. However, for many people eating animal protein is the only way to be truly healthy. I’m one of them.

      I just want to add that no matter what we eat we are part of nature, part of the birth, life, death cycle and never apart from it no matter what we do or think. As long as we’re in these bodies, at least. So eat what keeps you healthy and be grateful! That’s the best any of us can do besides stop eating altogether and we know pretty much how well that works out…

  15. I am hypo thyroid and it seems to be getting much better. It took an MD/ND/endocrinologist to properly diagnose me but once she did and put me on Armour thyroid I started feeling much better literally within half an hour of the first dose. It was quite the miracle for me. I ended up crashing a couple of months later with adrenal exhaustion and ended up pretty much in bed for a few months but once over that and continuing with lots of rest I am able to get around again. I’m still low energy, however, and I’m sure there’s more going on than “just” hypo thyroid and adrenal issues. Anyway, the point to my post is that at one time I was up to 120 mgs. of Armour, then down to 90, 60 and now I’m at 30 mgs. My current ND (the other doc retired, darn her!) says the progress is probably due to a tincture of ashwaganda which she has given me a couple of times. She says she’s seen hypo thyroid get much better because of it before. Don’t know if this is true for others but that’s my story so far.

  16. Hi Chris
    i was diagnosed hypo with a tsh of 5.5 i went to several different doctors and basically tried out higher doses of armour i am now on 1 grain and my tsh is around 3 do you think i would be able to stop taking my armour and be okay.im only 26 years old my dr said i should stay on it for life but i feel like my hypo was caused by starvation diets as a teen and low carb

  17. Great article! I have read your other posts on thyroid hormones, in particular the low-t3 series and found them very informative.

    I have personally been on Amour and slow- release t3 hormone. I was told I needed them due to a low free t3 level. I have just weaned off of the thyroid medication completely about three weeks ago, for the second time.
    I have never had such strong symptoms of fatigue, joint pain, brain fog, depression, weight gain and sugar cravings.
    I am wondering if you have ever seen thyroid hormones “return” to normal ( specifically free hormones) after being on thyroid hormone for a low t3. If so, is there a time frame?
    I am guessing it would vary with personal history, dosage, and thyroid hormone specifics. But I am beginning to have serious concerns that the Armor thyroid has done more permanent harm to my body than good.