9 Steps to Perfect Health - #4: Supplement Wisely | Chris Kresser

9 Steps to Perfect Health – #4: Supplement Wisely

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This content is part of an article series.

Check out the series here


In the first three articles in this series, we discussed which foods to eat and which foods to avoid. In this article we’re going to talk about when to supplement and how to do it wisely. We’ve got a lot of material to cover, so you might want to grab a cup of tea and get comfortable!

There are three principles to supplementing wisely:

  • Get nutrients from food whenever possible.
  • Take nutrients in their naturally occurring form whenever possible.
  • Be selective with your supplementation.

Get Nutrients from Food Whenever Possible

Humans are adapted to getting nutrients from whole foods. Most nutrients require enzymes, synergistic co-factors and organic mineral-activators to be properly absorbed. While these are naturally present in foods, they are often not included in synthetic vitamins with isolated nutrients.

In a paper published in the American Journal of Clinical Nutrition called Food Synergy: An Operational Concept For Understanding Nutrition emphasizing the importance of obtaining nutrients from whole foods, the authors concluded:

A person or animal eating a diet consisting solely of purified nutrients in their Dietary Reference Intake amounts, without benefit of the coordination inherent in food, may not thrive and probably would not have optimal health. This review argues for the primacy of food over supplements in meeting nutritional requirements of the population.

They cautioned against the risk of reductionist thinking, which is common in conventional medicine and nutritional supplementation. Instead, they urge us to consider the importance of what they call “food synergy”:

The concept of food synergy is based on the proposition that the interrelations between constituents in foods are significant. This significance is dependent on the balance between constituents within the food, how well the constituents survive digestion, and the extent to which they appear biologically active at the cellular level.

They go on to provide evidence that whole foods are more effective than supplements in meeting nutrient needs:

  • Tomato consumption has a greater effect on human prostate tissue than an equivalent amount of lycopene.
  • Whole pomegranates and broccoli had greater antiproliferative and in vitro chemical effects than did some of their individual constituents.
  • Free radicals were reduced by consumption of brassica vegetables, independent of micronutrient mix.

In short: get nutrients from food, not supplements, whenever you can.

Take Nutrients in Their Naturally Occurring Form Whenever Possible

Synthetic, isolated nutrients don’t always have the same effect on the body. It matters whether the nutrients have been produced by technologic or biological processes, because industrial processing sometimes creates an entirely new compound with different physiological actions.

Trans fat produced in ruminant animals (such as conjugated linoleic acids in dairy products) are beneficial to health, whereas trans fats produced in the processing of industrial seed oils are highly toxic.

Folic acid is another example. The naturally occurring form of folate is not folic acid, a compound not normally found in food or nature, but tetrahydrofolate. While folic acid can be converted into folate, that conversion is poor in humans. It’s also important to note that unlike natural folate, folic acid does not cross the placenta. This is significant because folate is a crucial nutrient for pregnancy, and while folic acid can prevent neural tube defects it doesn’t have the other beneficial effects of folate. What’s more, several studies have shown that folic acid – but not natural folate – increases cancer risk. Unfortunately, folic acid is what’s often used in multivitamins, because it’s significantly cheaper than natural folate.

Be Selective with Your Supplementation.

Multivitamins have become increasingly popular: half of Americans currently take one. But is this a good idea? Most studies show that multivitamins either provide no benefit, or may even cause harm. A study in the Archives of Internal Medicine showed that multivitamins have little to no influence on the risk of common cancers, CVD or total mortality in postmenopausal women. A now infamous meta-analysis in the Journal of American Medical Association, which looked at over 68 trials with 230,000 pooled participants, found that treatment with synthetic beta carotene, vitamin A and vitamin E may increase mortality.

The problem with multivitamins is that they contain too little of beneficial nutrients like magnesium, vitamin D and vitamin K2, and too much of potentially toxic nutrients like folic acid, calcium, iron and vitamin E. This means that multivitamins can actually cause nutrient imbalances that contribute to disease. Another problem is that multivitamin manufacturers often use the cheapest possible ingredients, such as folic acid instead of natural folate – the consequences of which we discussed above.

Which Supplements May Be Necessary?

At this point you might be thinking I’m against supplementation entirely. Not so. No matter how well we eat, some nutrients are difficult to obtain enough of from food alone. There are also circumstances where are need for certain nutrients may increase, such as vitamin C during infections and magnesium with blood sugar imbalances or metabolic problems. In these cases, it makes sense to supplement selectively with beneficial nutrients.

The five nutrients I recommend most people supplement with are:

  • Vitamin A
  • Vitamin D
  • Vitamin K2
  • Magnesium
  • Vitamin C

Vitamin A (Retinol)

Vitamin A is important catalyst for a variety of biochemical processes in the body. It’s required for assimilation of protein, minerals and water-soluble vitamins, and it also acts as antioxidant > protecting body against free-radical damage and diseases like cancer. Vitamin A plays a crucial role in reproduction, promoting full-term pregnancy and proper development of face (eyes, nose, dental arches & lips).

The RDA for vitamin A (2,600 IU) is woefully inadequate, and even then, over 25% of American consume less than half of the recommended amount. Native populations such as the traditional Inuit – which were free of modern, degenerative disease – got much more vitamin A than the average American. The Greenland Inuit of 1953, prior to much contact with the Western world, got about 35,000 IU of vitamin A per day.

Vitamin A (retinol) is only found in significant amounts in organ meats, which explains why many Americans don’t get enough of it. If you follow my recommendations in #2: Nourish Your Body, and you do eat organ meats (especially liver), you’re probably getting enough vitamin A and thus don’t need to supplement. However, if you’re like most Americans and you’ve never eaten liver in your life, you would benefit from supplementing with A.

There’s been a lot of discussion in the media about the toxicity of vitamin A. Some researchers and doctors now recommend avoiding cod liver oil because of this concern. Even Dr. Mercola has jumped on the “vitamin A is toxic” bandwagon. But is this true?

It is true that vitamin A is potentially toxic. Some evidence suggests that excess vitamin A increases the risk of osteoporosis. For example, this study showed both low and high serum A carried double risk of fractures as did optimal levels.

But if we dig deeper we find that excess vitamin A only causes problems against a backdrop of vitamin D deficiency. In his excellent article Vitamin A on Trial: Does Vitamin A Cause Osteoporosis, researcher Chris Masterjohn summarizes evidence demonstrating that vitamin D decreases the toxicity of and increases the dietary requirement for vitamin A. Studies show that supplementing with vitamin D radically increases the toxicity threshold of vitamin A. In a hypothetical 160 lb. person, vitamin D supplementation increases the toxicity threshold of vitamin A to more than 200,000 IU/d. You’d have to eat 22 ounces of beef liver or take 5 TBS of high vitamin CLO each day to get this amount. Not likely!

To meet vitamin A needs (assuming you’re not up for eating organ meats), I recommend taking high vitamin cod liver oil (CLO) to provide a dose of 10-15,000 IU per day. Cod liver oil is really more of a food than a supplement, but since it’s not a normal part of people’s diet we’ll consider it as a supplement.

CLO is an ideal vitamin A source because it also contains vitamin D, which as we just learned, protects against the toxicity of A.

Vitamin D

Much has been written about the need for and benefits of vitamin D supplementation over the past several years – and with good reason. It’s absolutely critical for health, and up to 50% of Americans are deficient.

We can get vitamin D from two sources: food, and sunshine. Seafood is the only significant source of vitamin D, but you’d still have to eat a lot of it to get enough. 8-9 ounces of herring provides about 2,000 IU of vitamin D, which is a minimum daily requirement for most people to maintain adequate blood levels.

Sunlight converts a precursor called 7-dehydro-cholesterol in our skin to vitamin D3. This D3, along with the D3 we get from food, gets converted by the liver into 25-hyrdroxy-vitamin D (25D), which is what typically gets measured when you have a vitamin D test. The optimal 25D level is somewhere between 35 and 50 ng/mL.

Contrary to what some researchers and doctors have recommended, there’s no evidence that raising blood levels of 25D above 50 ng/mL is beneficial, and there’s some evidence that it may cause harm. Studies show that bone mineral density peaks at 45 ng/mL and then falls again as 25D levels rise above 45. Other studies have shown that the risk of kidney stones and CVD increase with high 25D levels, due to elevated serum calcium levels that accompany excess vitamin D.

However, we also know that vitamin A and vitamin K2 protect against vitamin D toxicity, and vice versa. As I explained in the vitamin A section, fat soluble vitamins exist in a synergistic relationship. It’s possible that the people in the studies above that experienced problems with excess 25D levels were deficient in vitamin A or K2, or both. This is why it’s so important to supplement with all of the fat-soluble vitamins together.

What about sunlight? Well, in summer mid-day sun with pale skin, 30 minutes of direct sunlight will produce 10-20,000 IU of vitamin D. But this is a best case scenario. With darker skin, or different times of year, or buildings that block the sunlight, or increased time spent indoors, we won’t be producing that much. It’s also true that aging, overweight and inflammation reduce our conversion of sunlight to vitamin D. This is why sunlight alone isn’t normally a sufficient source of vitamin D.

With this in mind, most people should supplement with D. The amount needed to maintain blood levels of 35-50 ng/mL varies depending on some of the factors I’ve listed above, but in my clinical experience it’s usually somewhere between 2,000 – 5,000 IU.

With vitamin D, it’s important to test your levels, begin supplementation, and then re-test a few months later to determine the correct maintenance dose.

As with vitamin A, the best source of vitamin D is high-vitamin cod liver oil. It contains not only vitamins A & D, but also natural vitamin E and other quinones.

Vitamin K2

Vitamin K2 may be the most important vitamin most people have never heard of. It’s needed to activate proteins and it also regulates calcium metabolism (keeping it in the bones and teeth where it belongs, and out of the soft tissue where it doesn’t belong). Elevated blood calcium significantly increases the risk of cardiovascular disease (CVD), which explains why vitamin K2 has been shown to prevent atherosclerosis and heart attacks. It also strengthens bones.

Unfortunately, many (if not most) of Americans are deficient in vitamin K2. It’s important to point out that vitamin K2 is not the same as vitamin K1, which is found in green, leafy vegetables like kale and collards. Some K1 is converted into K2 in our bodies, but that conversion is inefficient in humans. It is efficient, however, in ruminant animals – which is why grass-fed dairy is the most convenient source of vitamin K2 in the diet. This is only true in animals raised on pasture, because it is eating the K1-rich grass that allows them to convert it into K2.

Most people should aim for at least 100 mcg/d from a combination of food and supplements. If you eat a large amount of cheese from grass-fed cows and pastured egg yolks, you may be able to get this amount from food alone. 100 g of hard cheese contains 67 mcg, and 6 pastured egg yolks contain about 32 mcg. Otherwise, supplementation is probably beneficial. I recommend a dosage of 1 mg/d in the MK-4 form, which is the form of vitamin K2 found in pastured dairy and the one shown to have the most benefit in clinical studies. There is another form, MK-7, that is found in fermented foods like natto, but it has not demonstrated the same properties as MK-4 in clinical studies.

Magnesium

There are few compounds in the body more important to overall health than magnesium.

Over 300 enzymes need it, including every enzyme associated with ATP, and enzymes required to synthesize DNA, RNA and proteins. Magnesium also plays an important role in bone and cell membranes, as it helps to transport ions across the membrane surface.

Studies show that most Americans are deficient in magnesium. The median intake across all racial groups is far below the RDA, which is 420 mg/d for men and 320-400 mg/d for women. Although half of Americans take a multivitamin daily, most don’t contain enough magnesium to prevent nutrient deficiencies.

Magnesium is also difficult to obtain from food. Nuts and seeds are the highest source, but it’s difficult to eat enough of them to meet magnesium needs without getting too much polyunsaturated fat. Another issue is that magnesium levels in food have dropped as modern soils have become increasingly depleted. What this means is that if you’re not supplementing with magnesium, you’re probably not getting enough.

And magnesium deficiency is no small thing. It has serious – even fatal – consequences. It produces symptoms like muscle cramps, heart arrhythmias, tremor, headaches & acid reflux, and it’s associated with CVD, hypertension, metabolic syndrome, diabetes, migraines, PMS, asthma, hypothyroidism. In fact, it’s hard to find a modern disease magnesium deficiency isn’t associated with.

Because of this, I think everyone should supplement with magnesium. Intake of 400 – 800 mg/d from a combination of food and supplements is an optimal range to shoot for. Since most people get less than 250 mg/d from food, a dose of 400 – 600 mg/d in supplement form is ideal. I recommend using chelated forms of magnesium like glycinate and malate, because they’re better absorbed and tend to have fewer side effects.

Vitamin C

Vitamin C is needed for building the structural components of the body, and for maintaining levels of glutathione, the master antioxidant in the body. But vitamin C deficiency is also common: studies suggest that 34% of men and 27% of women don’t get enough. This is especially true for the elderly and those struggling with chronic illness.

400 mg/d is the saturation range in healthy people, and that number is probably higher in the elderly and the sick. As with the other micronutrients in this article, it’s difficult to obtain adequate levels of vitamin C from the diet. Acerola cherries are the highest food source, with 1677 mg per 100g. A cup of cooked red peppers has 235 mg, which is one of the highest dietary sources.

I’m somewhat less certain about the need to supplement with vitamin C, but in general I recommend approximately 500 mg to 1 g of vitamin C each day. If you’re dealing with a chronic health challenge, or fighting an infection, you can take several grams a day with no toxic effects. It’s best to space the doses out to avoid diarrhea, however.

Other Contenders

In addition to the fat-soluble vitamins A, D & K2, and magnesium and vitamin C, some may want to consider supplementing with selenium and iodine. Selenium plays important role in thyroid function, which affects every aspect of physiology. The recommended dose is approximately 200 mcg/d.

Selenium is plentiful in organ meats, ocean fish, and in brazil nuts. One brazil nut contains 100 mcg of selenium, but it also contains a whopping 1 g of omega-6 linoleic acid, which as you know from previous articles in the series, we want to limit significantly. This is why I don’t recommend brazil nuts as a source of selenium. Ocean fish are also good sources of selenium. 100 g of cod contains about 150 mcg.

Iodine also plays a crucial role in thyroid function, and it prevents brain damage and strengthens the immune system. The amount iodine needed for thyroid function is incredibly small: we need about a teaspoon of iodine over a lifetime to avoid deficiency.

I’m not convinced humans need to supplement with iodine above what can be obtained from seafood, but some research does suggest that increased intake of iodine is beneficial. This is especially true if you’re fighting a chronic infection or dealing with a hypothyroidism caused by iodine deficiency.

But be careful: iodine can trigger and flare autoimmune diseases, especially Hashimoto’s and Graves'(autoimmune thyroid disease). In the U.S., 9 out of 10 women with hypothyroidism actually have Hashimoto’s, so the typical advice to supplement with iodine if you are hypothyroid is dangerous. I’ve written extensively about this in my special report on thyroid disease.

For those without autoimmune disease, a dose of 12.5 mg – 50 mg per day may be beneficial, but it’s best to work up slowly over time, beginning at a much lower dose.

170 Comments

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  1. The concept of food synergy provides the necessary theoretical underpinning. The evidence for health benefit appears stronger when put together in a synergistic dietary pattern than for individual foods or food constituents.

  2. Great article! Often it’s lifestyle that makes nutrition so difficult. Who has time? Take a little time to know how best to eat, which foods are best for which nutrients, and, as you exemplified, how helpful the right vitamins can be are all key ingredients to healthy living.

    Jerry Costman | Go Fuel Club

  3. Good steps for perfect health and which protein used for improve muscles and strength of body after workout… thanks for sharing more beneficial information………………….

  4. Chris, thank you for this phenomenal article that so closely matches the health protocols that I follow in my own healthy endeavors. I would like permission to replicate this article for the benefit of my circles of friends with your permission.
    I would also like to respectfully add a few thoughts.
    I agree with Helen’s posting on:
    AUGUST 3, 2014 AT 1:11 PM
    I think many are iodine deficient in addition to the nutrients you listed in the article.
    Most Vitamin C supplements are ascorbic acid, which is not Vitamin C.
    It is a good idea to mix in some magnesium threonate to the magnesium regimen. It’s the only form that will pass the blood brain barrier.
    Contact me for references Chris.

  5. Hi Chris,

    I have been doing a lot of research recently, including your excellent website, but to be honest I am only becoming more and more confused with the conflicting information available!

    I do not consider myself to be “unhealthy” as such but do feel I could beenfit from supplementation as my diet is not always what it should be (alcohol/refined carbs etc).

    My plans for supplements have ranged from multivitamins/fish oil/chlorella/green powders in smoothies and so on. I try to eat oily fish but simply do not enjoy the taste, even more so the green powders.

    Having read your posts recently I am becoming convinced to look at replacing these with the fermented cod liver oil (FCLO). Can you please confirm if you consider the Green Pastures Butter Blend to be superior, or just to take the standard cod liver oil?

    Also, I am still interested in taking a form of chlorella/sprirulina supplement, but am slightly concerned about the level of Vitamin A I would be consuming. Would you consider such an approach to be within safe levels? I do not eat any liver and as far as I am aware no other foods contain significant levels of Vit A?

    Also if I do this (mainly to try to stick as much to whole foods as possible) would you consider me to be at risk of a deficiency in any other area (B vitamins etc)? I try to eat a fairly varied diet including meat/veg/fruit/nuts etc…

    Many thanks,

    John

  6. From this blog we get to know about which and when supplement should be taken. As we all know that food is the natural source of nutrients and we all should take nutrients from the food whenever it is possible instead of supplements. Supplement should be taken with proper consultation of doctor or health expert as it can be harmful for our body if not taken appropriately. Supplement should be taken if there is deficiency of nutrients in the body or as per the need.

  7. I must caution you that MK7 is actually preferred over MK4 when taken in supplement form. That is because it is able to keep its natural properties; but MK4 is not able to be produced in supplement form from natural sources. It is produced from the tobacco plant. And actually, the MK7 form is more bio available and better absorbed as well.

  8. Hi chris,

    Excellent post. Thank you for discussing the difference between folic acid and folate. I am body builder and i am using
    optimum nutrition glutamine which is rich in amino acid. Does artificial amino acid used in supplements have any side effects?

  9. hi, chris.

    is there any harm in supplementing with 12mg of astaxanthin per day?

    while i like the fact that my skin seems to burn less easily and looks more supple when taking it, i am concerned about the high anti-oxidant content.

    furthermore, do you have any general thoughts on astaxanthin?

    many thanks!

  10. Iodine – Stop the fear mongering. Iodine is a necessary nutrient. That was why it was added to salt – a necessary nutrient. Unfortunately, though regular salt is unhealthy because it doesn’t have the companion trace minerals in its natural form. Best to consume & even add Celtic/Himalayan Salt to your drinking water, but you don’t get the iodine.
    Also, once you open up iodized salt, the iodine evaporates, so you are NOT getting the iodine in your daily salt anyway.

    Iodine was used by all doctors to treat nearly all ailments (due to so much deficiency in the diet) for many years until..yes, guess what… until the pharmaceutical companies started pushing thyroid drugs. Drugs that don’t fix the problem, but “manage” while they profit greatly. Thyroid meds actually require MORE iodine supplementation. Your thyroid, heart, brain, major organs NEED iodine. And it takes awhile of larger doses to get these organs saturated to start working properly again and to stop cancer.

    Breast cancers and prostate cancers are being cured with iodine. Don’t believe it?, then do your research, but based on those doctors/researchers who actually have treated with iodine and not the media/bigPharma controlled ones or those that just have been trained improperly and haven’t unlearned the b.s. Do your own research and make your own choices, but at least check out these sources below and many more, once you start to learn who to actually trust.

    Educate yourself about why you DO need to supplement with iodine. One of the biggest reasons is that iodine was an ingredient in bread-making, but was replaced by bromides which the body will absorb more readily than iodine, making us even more iodine-deficient and toxic. Here are some links to handouts on how to supplement safely with links to sources. Even Hashimotos and Graves patients can supplement safely with iodine, but you MUST do the reading to help yourselves. Don’t believe the same doctors’ fear-mongering about iodine – the same doctors who push unhealthy cholesterol drugs which are managing a false condition and are making people so much more sick while they profit.

    I belong to a Facebook iodine group and have learned so much from the members there who share their experiences. Real people; real experiences, based on real research from people who care and aren’t out to take your $.

    These are just a few links I took the time to find and share. But from here you can find tons of other articles and youtube videos on the subject to watch if you learn better from hearing the information.

    http://www.drbrownstein.com/Iodine-Why-You-Need-It-p/iodine.htm

    http://www.oasisadvancedwellness.com/learning/iodine-deficiency-under-recognized-epidemic.html

    https://docs.google.com/document/d/1IzFKo-r2-Nn8_z0KUrOhHdlanzSuhkuV3QO03XF6YTY/edit?pli=1

    http://iodine4health.com/basic/iodinegroup.htm

  11. Hi Chris,

    Great article, thanks. Sorry if you have already answered this, but would I get enough k2 from high vitamin butter oil plus about 2 tablespoons of grass-fed ghee and 3-6 pastured egg yolks per day? Is there any need to supplement with k2 on top of this?

    Also, a question about FCLO – vitamins aside, is there enough EPA/DHA in this that there would be no need to supplement fish oil. I rarely eat oily fish, but do always eat grass-fed meat. I currently supplement 1 tsp fish oil per day. I am wondering whether the FCLO could replace this.

    Thanks,
    Barclay

  12. Hello..I am reading all these discussions and wanted to know more about two things. I take Nordic Naturals, Arctic D Cod Liver Oil…there is so much debate out there between this one and Green Pastures. I have been taking it for awhile and have felt great, but I don’t want to be putting toxic synthetic stuff in me. There is so much out there that it gets darn confusing for us all to know what is best. And has anyone heard about Juice Plus? I hear its amazing because it is whole foods encapsulated.

  13. 12.5 – 50 mg of iodine is dangerous and potentially lethal (thyroid cancer). Japanese intake is on average 1000 to 3000 mg via seaweed in their diet. Of that, even less is actually absorbed into their bloodstream. Supplements absorb more readily and quickly. The fact that people suggest building up a “tolerance” to excessive levels is telling. A tolerance to iodine simply means your thyroid is over saturated and is no longer absorbing nearly as much (in order to save you from yourself) AND your kidneys are flooding your urine with the excess iodine to get it out of your body (in order to save you from yourself). You should NEVER try to build up a “tolerance” to extreme dosages of supplements.

    On average, you are currently consuming 40 to 70 mcg per day. If you actually needed 12.5 to 50 mg a day you would be dead right now due to massive lack of iodine. It is you may have a microgram deficit and not truly realize it. It is impossible to need 12.5 to 50 mg of something each day, only get 70 mcg of that substance each day and not have major symptoms such as goiter or even death. You may be getting 40 to 70 mcg a day (on average) but actually need 200 to 300 mcg. You still are low but the difference is not so drastic that it has caused a goiter or killed you yet. There is absolutely ZERO logic to the 12.5 to 50 mg recommendation.

    This is a very dangerous and potentially lethal daily dose of iodine, which can result in thyroid cancer many years later. When 26% of the people develop health issues from iodine toxicity, will they realize it was the excessive iodine that caused it? When another 24% of the people who chose to megadose on iodine develop cancer 15 years from now I am certain they will regret taking such massive doses of iodine. DO NOT TAKE MASSIVE DOSES OF IODINE!

  14. Chris,

    A Cyrex lab test showed I was cross-reactive to Milk Butyrophilin. I would like to take Green Pastures butter capsules for K2. Can you tell me if butter oil contains the Milk Butyrophilin protein? Thank you.

  15. Hi Chris,
    I have a severely compromised digestive system, I’ve been eating Gaps/scd/paleo for over 10 years with no relief. My diet is highly restrictive. I’ve been contemplating taking Barley Grass( I have a sample ) however I am hesitant. I know I need extra nutrients. As I cannot eat fish, eggs, chicken and most veggies or fruit. diet consists of sweet potatoes, squash, most meats, romaine, sauerkraut, olives, ghee/coconut oil, tiny amount of nut butters. I need more nuutrients, as I am basically eating once a day. … any feed back on “grass powders”?? Thank you!! Dora

  16. Timeless article Chris.
    How important is timing and combination of these supplements. I know some affect the absorption of others and some may be better in the morning, with our without meals?

    Thanks in advance and please keep up your good work.
    -Joe